NCT05836090

Brief Summary

This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigators aim to address this gap by testing the effectiveness of a trans-diagnostic secondary prevention program, Family Spirit Strengths (FSS) that can be embedded within home visiting services. The FSS program is a skills-based program that incorporates elements of evidence-based practice, the Common Elements Treatment Approach (CETA), and materials informed and developed based on an Indigenous advisory group. The FSS program aims to help participants build self-efficacy and coping skills, as well as build stronger connections to others, the participants' community, and cultural resources. The investigators will use a randomized controlled trial, whereby half of the participants will receive FSS and the other half will receive an evidence-based nutrition education program. The investigators' study is grounded in participatory processes and led by a team of Indigenous and allied researchers.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
188

participants targeted

Target at P75+ for not_applicable

Timeline
26mo left

Started Apr 2023

Longer than P75 for not_applicable

Geographic Reach
1 country

3 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress59%
Apr 2023Jun 2028

First Submitted

Initial submission to the registry

April 18, 2023

Completed
2 days until next milestone

Study Start

First participant enrolled

April 20, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

May 1, 2023

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2028

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2028

Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

4.9 years

First QC Date

April 18, 2023

Last Update Submit

April 10, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Difference in number of poor mental health days in last 30 days as assessed by a single item on the Health-Related Quality of Life (HRQOL) measure

    As measured by the single item on the Health-Related Quality of Life (HRQOL) which asks responders to identify how many days in the past 30 day they experience bad or poor mental health. Scores may range from 0-30 where 0 indicates the participant did not experience any poor mental health days in the last 30 days and 30 indicates the participant experienced a poor mental health day every day in the last 30 days. A difference in mean for the past 30 days will be calculated at the 6 month follow-up timepoint.

    baseline, 3-4 months post baseline, 6-8 months post baseline

Secondary Outcomes (3)

  • Change in Substance Use as measure by the Timeline Follow Back for Substance Use

    baseline, 3-4 months post baseline, 6-8 months post baseline

  • Change in depressive symptoms as measured by the Centers for Epidemiological Research Revised 10 item scale (CESDR-10)

    baseline, 3-4 months post baseline, 6-8 months post baseline

  • Change in anxiety symptoms as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS) short form

    baseline, 3-6 months post baseline, 6-8 months post baseline

Study Arms (2)

Family Spirit Strengths (FSS)

EXPERIMENTAL

FSS participants will receive 4-16 (average of 6-8) intervention visits covering topics related to their mental and behavioral health. The number of sessions each participant receives varies and depends on their unique needs. To guide this process, all intervention participants will take a brief, in-session survey to screen for current challenges they may be facing. Their answers will help determine the content and dose of future sessions.

Behavioral: Family Spirit Strengths (FSS)

Family Spirit Nurture

ACTIVE COMPARATOR

Participants enrolled in nutrition education comparison group will receive 6 educational lessons related to promoting early childhood healthy growth. Lessons will be delivered bi-weekly for no longer than 4-months total. The lessons are from the evidence-based Family Spirit Nurture curriculum.

Behavioral: Family Spirit Nurture

Interventions

The FSS intervention consists of psychoeducational components that emphasize the importance of mental and emotional health as part of overall wellness, and seek to normalize experiences of stress, to de-stigmatize help-seeking, and to build hope. Core content focuses on awareness of the connections between thoughts, feelings, behaviors, and spirituality, and imparts related self-help skills. It also specifically builds in connection to culture, land and others as coping strategies. The FSS lessons were developed based on culturally adapting the Common Elements Treatment Approach (CETA).

Family Spirit Strengths (FSS)

The active control Family Spirit Nurture, is an evidence-based nutrition education curriculum that has been previously tested with Navajo communities which focuses on age-appropriate parental feeding practices, including snack routines, avoidance of sugar-sweetened beverages (SSB) and promotion of water consumption.

Family Spirit Nurture

Eligibility Criteria

Age14 Years+
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsIdentifies as female
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Self-identify as female; and
  • Pregnant or be a primary caregiver of a child that is 24 months or younger; and
  • years or older at time of enrollment; and
  • Report a family history of high-risk substance use and/or report high-risk levels of personal substance use; and
  • Have elevated symptoms of depression and/or anxiety and/or risk of substance use disorder; and
  • Be part of the service population of one of the participating sites.

You may not qualify if:

  • Profound disability that limits the ability to participate in assessments or interventions; and
  • Unlikely to be residing in or near the research service area for the next 6 months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Johns Hopkins Center for Indigenous Health

Chinle, Arizona, 86503, United States

RECRUITING

Pokagon Health Services

Pokagon, Michigan, 49047, United States

RECRUITING

Johns Hopkins Center For Indigenous Health

Shiprock, New Mexico, 87420, United States

RECRUITING

Related Links

MeSH Terms

Conditions

DepressionAnxiety DisordersSubstance-Related Disorders

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorMental DisordersChemically-Induced Disorders

Study Officials

  • Emily Haroz

    Johns Hopkins Bloomberg School of Public Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Emily Haroz, PhD

CONTACT

Leonela Nelson, MPH

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 18, 2023

First Posted

May 1, 2023

Study Start

April 20, 2023

Primary Completion (Estimated)

March 30, 2028

Study Completion (Estimated)

June 30, 2028

Last Updated

April 13, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations