Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome

NCT05830370 | Unknown

• 1 other identifier: Soh-Med-23-04-23MS
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel movements, sense of incomplete evacuation after bowel movements or sense of urgency to move the bowels.Several parasites including Entamoeba. histolytica, Giardia spp., Blastocystis. hominis, and Trichinella spp. have been discussed as contributing factors to the development of IBS. B. hominis is one of the most common human intestinal protozoa in both developing and developed countries. some studies have reported a significant association between the parasitic infections, especially Blastocystis, and IBS.Cryptosporidium has been reported in IBS patients, with the onset of gastrointestinal symptoms after an acute episode of cryptosporidiosis despite recovery and parasite clearance.Numerous studies have been conducted to evaluate the association between the parasitic infections and IBS. Aim of the work: To detect prevalence of intestinal parasitic infections in irritable bowel syndrome patients in sohag.

Conditions

Irritable Bowel Syndrome

Keywords

irritable bowel syndrome; entamoeba; histolytica; Blastocystis; hominis; chronic abdominal pain; diarrhea; defecation; constipation; bloating; Trichinella; Cryptosporidium

Outcome Measures

Primary Outcomes (1)

• To detect prevalence of intestinal parasitic infections in irritable bowel syndrome patients in sohag.

  will collect 200 stool samples : 100 samples will be collected from patients complaining of symptoms of IBS fulfilling the Rome criteria , such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups from different locations (cities and village) And 100 samples healthy controls.the samples will be examined for parasitological examination to detect prevalence of intestinal parasitic infections in irritable bowel syndrome patients.

  16 weeks following the startpoint of the study.

Study Arms (2)

case

patients complaining of symptoms of IBS fulfilling the Rome criteria , such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups from different locations.

control

healthy individuals not suffering from IBS symptoms such as abdominal discomfort, diarrhea, and constipation, bloating.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

samples will be collected from outpatients complaining of symptoms of IBS fulfilling the Rome criteria , such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups from different locations (cities and village).

You may qualify if:

• Patients complaining of symptoms of IBS, such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups

You may not qualify if:

• Patients have celiac disease, gastrointestinal malignancies , inflammatory bowel disease , HIV , and those on immunosuppression and those who had been recently taking antibiotics within the previous four weeks and anti-parasitic drugs within the previous two weeks.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Faculty of Medicine Sohag University

Sohag, 093, Egypt

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

stool specimens

MeSH Terms

Conditions

Irritable Bowel Syndrome; Diarrhea; Constipation

Condition Hierarchy (Ancestors)

Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Nada Mahmoud Ahmed

CONTACT

01069122479; nadamahmoud@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator at medical parasitology department.

Study Record Dates

• First Submitted: April 12, 2023
• First Posted: April 26, 2023
• Study Start: May 1, 2023
• Primary Completion: November 30, 2023
• Study Completion: January 1, 2024
• Last Updated: April 26, 2023

Record last verified: 2023-04

Locations

EG (1)