Immunological Indices and Infections Among Pesticide Applicators in Sohag Governorate
1 other identifier
interventional
60
1 country
1
Brief Summary
The human body gets exposure to pesticides either directly or indirectly. By using pesticides on crops, humans come in direct contact with them and they affect the heaith Immune system is the first defense line against pathogenic organisms; however, it is altered by the vulnerable environmental factors such as pesticides, which can cause structural or functional alterations in humoral or cell mechanisms (nonspecific or adaptive) of the immune response which lead to an increase in the susceptibility to infections
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 13, 2023
CompletedFirst Posted
Study publicly available on registry
April 25, 2023
CompletedStudy Start
First participant enrolled
May 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2024
CompletedApril 25, 2023
April 1, 2023
1 year
April 13, 2023
April 13, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
immunlogical indices
immunoglobulins (IgG ,IgE)
12 months
Study Arms (2)
pesticide applicators
ACTIVE COMPARATORThis group contain cases
control
ACTIVE COMPARATORcontrol group
Interventions
Blood sample will be taken to determine immunological indices
Eligibility Criteria
You may qualify if:
- pesticide applicators
- Age ;20-60 years
- Exposure to pesticides for more than 3 months
You may not qualify if:
- Subjects have recent severe trauma or surgery or recent infections
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Sohag Universitylead
Study Sites (1)
Sohag University
Sohag, Egypt
Related Publications (3)
Hadnagy W, Leng G, Sugiri D, Ranft U, Idel H. Pyrethroids used indoors--immune status of humans exposed to pyrethroids following a pest control operation--a one year follow-up study. Int J Hyg Environ Health. 2003 Mar;206(2):93-102. doi: 10.1078/1438-4639-00201.
PMID: 12708230BACKGROUNDKalyabina VP, Esimbekova EN, Kopylova KV, Kratasyuk VA. Pesticides: formulants, distribution pathways and effects on human health - a review. Toxicol Rep. 2021 Jun 6;8:1179-1192. doi: 10.1016/j.toxrep.2021.06.004. eCollection 2021.
PMID: 34150527BACKGROUNDZhang W, Lin Z, Pang S, Bhatt P, Chen S. Insights Into the Biodegradation of Lindane (gamma-Hexachlorocyclohexane) Using a Microbial System. Front Microbiol. 2020 Mar 27;11:522. doi: 10.3389/fmicb.2020.00522. eCollection 2020.
PMID: 32292398BACKGROUND
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- DEMONSTRATOR
Study Record Dates
First Submitted
April 13, 2023
First Posted
April 25, 2023
Study Start
May 1, 2023
Primary Completion
May 1, 2024
Study Completion
May 1, 2024
Last Updated
April 25, 2023
Record last verified: 2023-04