Effect of Sarcopenic Obesity on Weight Loss Outcomes and Quality of Life After Laparoscopic Sleeve Gastrectomy

NCT05826210 | Completed DMC

• 1 other identifier: 2023-03
• Study Type: observational
• Target: 245
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the impact of sarcopenic obesity (SO) on weight loss outcomes and improvement of quality of life after laparoscopic sleeve gastrectomy.

Conditions

Sarcopenic Obesity; Body Composition

Keywords

laparoscopic sleeve gastrectomy; weight loss; sarcopenic obesity; Fat-free mass; Quality of life

Outcome Measures

Primary Outcomes (1)

• %EWL

  Percentage excess weight loss is calculated as (initial weight - 6-month weight)/(initial weight - ideal weight) × 100%.

  6 month after surgery

Secondary Outcomes (10)

• %EWL

  1 month after surgery

• %EWL

  3 month after surgery

• %EWL

  9 month after surgery

• %EWL

  12 month after surgery

• %TWL

  6 month after surgery

Study Arms (2)

Sarcopenic obesity group

Patients who underwent LSG with FM/FFM\>0.80 calculated from the cross-sectional CT image of L3 vertebra.

Procedure: Laparoscopic sleeve gastrectomy

Non-sarcopenic obesity group

Patients who underwent LSG with FM/FFM\<0.80 calculated from the cross-sectional CT image of L3 vertebra.

Procedure: Laparoscopic sleeve gastrectomy

Interventions

Laparoscopic sleeve gastrectomy PROCEDURE

Laparoscopic sleeve gastrectomy was performed in all patients with or without SO.

Non-sarcopenic obesity group; Sarcopenic obesity group

Eligibility Criteria

• Age: 16 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This retrospective monocentric study included 260 obese patients who underwent LSG between January 2015 and July 2022 at the Department of Gastric Surgery, Fujian Medical University Union Hospital. All patients underwent a thorough multidisciplinary evaluation (an endocrinologist, dietician, and bariatric surgeon), and a psychiatric evaluation was obtained if considered necessary. All patients completed routine preoperative investigations, including upper gastrointestinal endoscopy, chest radiography, abdominal computed tomography (CT), abdominal ultrasound examination, and nutritional assessment. Preoperative QOL was measured using the Moorhead-Ardelt questionnaire at the same visit. All patients in this study were operated on by the same surgical team of surgeons with more than 60 LSG experiences.Postoperative treatment was performed based on the patient's condition.

You may qualify if:

• Obese patients who met the indications for LSG and were followed up regularly as planned after surgery.

You may not qualify if:

• incomplete critical clinical data;
• incomplete imaging data;
• insufficient follow-up data.

Sponsors & Collaborators

• Fujian Medical University: lead

Study Sites (1)

Chang-ming Huang

Fuzhou, Fujian, 350001, China

Location

Related Publications (16)

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MeSH Terms

Conditions

Weight Loss

Condition Hierarchy (Ancestors)

Body Weight Changes; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Chang-Ming Huang, Ph.D

  Fujian Medical University Union Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: April 12, 2023
• First Posted: April 24, 2023
• Study Start: January 1, 2015
• Primary Completion: July 1, 2022
• Study Completion: December 31, 2022
• Last Updated: April 24, 2023

Record last verified: 2023-04

Locations

CN (1)