NCT05820659|CompletedResults
Racial Discrimination and Stress Response
Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
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Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
Sponsor study identifier
interventional
178
1 country
1
Study Start
June 29, 2023
Actual (reported)Primary Completion
November 17, 2024
Actual (reported)Study Completion
November 17, 2024
Actual (reported)The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 17, 2024
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 29, 2023
Actual (reported)April 20, 2023
Actual (reported)June 29, 2023
Actual (reported)November 17, 2024
Actual (reported)November 17, 2024
Actual (reported)August 17, 2026
Actual (reported)Change in Mean Arterial Pressure for Peer Rejection
adolescents' diastolic and systolic blood pressure will be continuously monitored.
baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
Change in Stress Hormones for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for cortisol.
five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Change in Inflammatory Biomarker of Interleukin 6 for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Change in Inflammatory Biomarker of C-reactive Protein for Peer Rejection
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Change in Mean Arterial Pressure for Impossible Puzzle
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Emotional Experience for Impossible Puzzle
immediately after the 5-minute impossible puzzle task ends
Attribution for Impossible Puzzle
immediately after the 5-minute impossible puzzle task ends
Change in Skin Conductance for Impossible Puzzle
baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
Change in Respiratory Sinus Arrhythmia for Impossible Puzzle
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, then discuss the peer rejection task with parents, as well as an impossible puzzle task to elicit cognitive stress.
Peer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software. Conversation about peer rejection: parents and adolescents will discuss the peer rejection task guided with suggested question prompts. Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Western Kentucky University
Bowling Green, Kentucky, 42101, United States
Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
Qingfang Song, Ph.D
Western Kentucky University
178 participants (actual enrollment reported by the registry).
First Submitted
March 29, 2023
First Posted
April 20, 2023
Study Start
June 29, 2023
Actual (reported)Attribution About the Peer Rejection for Peer Rejection
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale. The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
immediately after the 5-minute peer rejection task ends
Emotional Experience for Peer Rejection
adolescents will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
immediately after the 5-minute peer rejection task ends
Change in Skin Conductance Activity for Peer Rejection
adolescents' skin conductance will be continuously monitored for the peer rejection task.
baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
Change in Respiratory Sinus Arrhythmia for Peer Rejection
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
Contact the study team to confirm eligibility.
Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
Primary Completion
November 17, 2024
Actual (reported)Study Completion
November 17, 2024
Actual (reported)Last Updated
August 17, 2026
Results First Posted
August 17, 2026
Record last verified: 2026-08
The research resources from the project will include the study protocol and associated data, which will be provided upon request.
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Source: ClinicalTrials.gov.
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