The Assessment of Curcuma Longa Potentials for Soft and Hard Tissue Healing in Fresh

NCT05816707 | Completed Phase 1

• 1 other identifier: REC-D652-3
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The study will be conducted on 30 patients with split mouth design patients will be divided into curcumin and PRF groups patients will have bilateral tooth extraction one side will receive curcumin/PRF and the other side will be control soft tissue healing and bone quality will be evaluated post-operative

Conditions

Tooth Extraction Status Nos; Tooth Fracture

Outcome Measures

Primary Outcomes (1)

• Soft tissue healing

  Healing index (change is being assessed)

  21 days after surgery

Secondary Outcomes (1)

• Bone Density

  3 months after surgery

Study Arms (3)

Control

OTHER

extraction socket .

Other: extraction socket

PRF Group

ACTIVE COMPARATOR

extraction socket and PRF

Biological: PRF; Other: extraction socket

Curcuma Longa Group

ACTIVE COMPARATOR

Extraction Socket and Curcuma Longa

Biological: Curcuma Longa gel; Other: extraction socket

Interventions

PRF BIOLOGICAL

Teeth will be extracted a-traumatically as possible to avoid any soft tissue or bony damage. The extracted sockets will be debrided by bone curettes and saline. The three extraction sockets will be divided into three groups: control group, curcumin group, and PRF group. After curcumin/ PRF placement, all sockets will be closed by simple interrupted suture

PRF Group

Curcuma Longa gel BIOLOGICAL

Curcuma Longa gel

Curcuma Longa Group

extraction socket OTHER

extraction socket

Control; Curcuma Longa Group; PRF Group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \. Patients with bilateral badly decayed mandibular posterior tooth that need extraction.
• \. Patients free from any systemic disease 3. Patients who approved to be included in the trial and signed the informed consent.
• \. Patients with no signs or symptoms of acute periapical\\ periodontal infection.
• \. Adults aged between 18-50 years old.

You may not qualify if:

• \. Patients who are allergic to Curcumin 2. Smoker patient 3. Patients receiving chemotherapy or radiotherapy. 4. Patients who refused to be included in the trial.

Sponsors & Collaborators

• Rania Farouk Mohamed Abdulmaguid: lead

Study Sites (1)

Rania Farouk

Cairo, 12855, Egypt

Location

MeSH Terms

Conditions

Tooth Fractures

Condition Hierarchy (Ancestors)

Tooth Injuries; Tooth Diseases; Stomatognathic Diseases; Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor Oral medicine and periodontology faculty of dentistry MSA university

Model Details: Randomized controlled clinical trial.

Study Record Dates

• First Submitted: March 19, 2023
• First Posted: April 18, 2023
• Study Start: May 1, 2024
• Primary Completion: February 1, 2026
• Study Completion: March 1, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-03

Locations

EG (1)