NCT05815810|Not Yet Recruiting
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Sponsor study identifier
interventional
50
1 country
2
Study Start
October 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The investigators hypothesize that the mobile application they developed for transgender and gender diverse individuals (TGGD) will be equivalent or better than traditional speech therapy in improving voice quality. The investigators will measure both how the participants feel about their voices and how their voice actually sounds to see if the app is effective.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 3, 2023
Actual (reported)April 18, 2023
Actual (reported)October 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change in Transsexual Voice Questionnaire (TVQ) Scores
The Transsexual Voice Questionnaire (TVQ) is a 30-item questionnaire that assesses self-perception of voice in transgender individuals. Responses range from (1) rarely or never to (4) usually or always. Scores range from 30 (no perceived voice difficulty) to 120 (high perceived voice difficulty).
Baseline, Week 4, Week 11
Change in Transgender Self Evaluation Questionnaire (TSEQ) Scores
The Transgender Self Evaluation Questionnaire (TSEQ) is a 30-item questionnaire that assesses self perception in transgender and gender diverse individuals. Responses range from (1) never (4) always. Scores range from 30 (low voice satisfaction) to 120 (high voice satisfaction)
Baseline, Week 4, Week 11
Change in Fundamental Frequency
The acoustic measure fundamental frequency will be obtained by analyzing participant's voice recordings via multi-speech acoustic analyses program of Kay-Pentax
Baseline, Week 4, Week 11
Change in Formants
The acoustic measure formants will be obtained by analyzing participant's voice recordings via multi-speech acoustic analyses program of Kay-Pentax
Baseline, Week 4, Week 11
Usability of Mobile Application as measured by the Mobile Application Rating Scale (MARS)
Week 11
The investigators will develop Attuned, an open access voice and communication modification training (VCMT) app based on standard of care. Participants will undergo VCMT via the mobile application, Attuned. Participants will include healthy transgender and gender diverse (TGGD) individuals seeking voice modification to better reflect their identity.
VCMT via speech pathology will be compared to the efficacy of an app-based VCMT program. Participants will undergo VCMT in-person. Participants will include healthy transgender and gender diverse (TGGD) individuals seeking voice modification to better reflect their identity.
Subjects will undergo voice and communication modification therapy via the Attuned application. This consists of an 11 week program consisting of different modules to learn how to modify voice (e.g., pitch, intonation, resonance). At the end of each module, participants will be given exercises to practice what they learned.
Subjects will undergo standard of care in-person voice modification therapy at Ithaca College.
Ithaca College
Ithaca, New York, 14850, United States
Weill Cornell Medicine
New York, New York, 10022, United States
Anaïs Rameau, MD
Weill Medical College of Cornell University
First Submitted
April 3, 2023
First Posted
April 18, 2023
Study Start
October 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
December 2030
EstimatedRegistry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
June 22, 2026
Record last verified: 2026-06
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Source: ClinicalTrials.gov.
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