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Outcome Measures

Primary Outcomes (1)

Total dose of morphine needed postoperatively
Total dose of morphine needed postoperatively
Through Study Completion Up to 1 Day

Secondary Outcomes (6)

Time to first rescue analgesia, starting after extubation
Through Study Completion over the first 24 hours postoperative
Duration of surgery
Through Study Completion 24 hours postoperative
Blood loss,
Through Study Completion,an average of 1day
Total dose of fentanyl required intraoperative (including induction dose)
Through study completion,an average of 1day
Pain score at 15, 30, 45 and 60 min., 3,6,12 and 24 h after surgery
through study completion,an average of 1day
+1 more secondary outcomes

Study Arms (2)

Group 1

ACTIVE COMPARATOR

Patients will preoperatively receive low concentration-high volume U/S ESP block, and then the patient will be transferred to the operating room one syringe of 30ml bupivacaine 0.25% {15 ml bupivacaine 0.5% and 15ml normal saline}, for each patient.

Drug: Group 1(low concentration-high volume bupivacaine US guided Erector Spinae Plane block)

Group 2

ACTIVE COMPARATOR

Patients will preoperatively receive high concentration-low volume U/S ESP block block, and then the patient will be transferred to the operating room one syringe of 15 ml bupivacaine 0.5% {15 ml bupivacaine 0.5% }, for each patien).

Drug: Group 2(high concentration-low volumecbupivacaine US guided Erector Spinae Plane block)

Interventions

Group 1(low concentration-high volume bupivacaine US guided Erector Spinae Plane block)Drug

Patients will preoperatively receive low concentration-high volume ultasound guided Erector Spinae Plane block, and then the patient will be transferred to the operating room ) one syringe of 30ml bupivacaine 0.25% {15 ml bupivacaine 0.5% and 15ml normal saline} for each patient

Also known as: Erector Spinae Plane Block with high volume-low concentration bupivacaine 0.25%

Group 1

Group 2(high concentration-low volumecbupivacaine US guided Erector Spinae Plane block)Drug

Study Design

Study Type

interventional

Phase

phase 2 3

Allocation

RANDOMIZED

Masking

DOUBLE

Who Masked

PARTICIPANT, INVESTIGATOR

Masking Details

Patients will be randomly allocated to one of the two groups by sealed closed envelop technique

Purpose

SUPPORTIVE CARE

Intervention Model

PARALLEL

Model Details: We hypothesize that high volume low concentration ultrasound-guided Erector Spinae Plane block is going to be more effective than low volume high concentration in patients undergoing MRM. Many authors advocate increasing the volume of injection in fascial plane blocks to allow better spread of local anesthetic according to multiple studies

Sponsor Type

OTHER

Responsible Party

PRINCIPAL INVESTIGATOR

PI Title

Professor of Anesthesia &I.C.U and Pain Clinic, Cairo University

Comparing the Perioperative Analgesic Effect of Two Different Volumes of Local Anesthetic Solution in Erector Spinae Plane Block in Patients Undergoing Modified Radical Mastectomy

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

Primary Completion

Study Completion

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (2)

Group 1

Group 2

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

Primary Completion

Study Completion

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (6)

Study Arms (2)

Group 1

Group 2

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations