Effects of Induced Inspiratory Muscle Fatigue on Functional Mobility of Older Adults

NCT05812651 | Completed DMC

• 1 other identifier: REC/01375 Qurat ul ain Gohar
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of study was to evaluate the effects of inspiratory induced muscle fatigue on functional mobility of older adults. Though, limited literature exists regarding inspiratory muscle fatigue and its consequences on functional activities of daily living and balance. Yet, it is not clear how improvement in inspiratory muscle strength is related with improvement in functional mobility.

Conditions

Healthy Older Adults

Keywords

Inspiratory muscle fatigue; Functional mobility; Maximum Inspiratory Pressure

Outcome Measures

Primary Outcomes (4)

• Six minute walk test

  The 6 Minute Walk Test is a sub-maximal exercise test used to assess aerobic capacity and endurance.

  After 3 days

• 30sec sit to stand test

  The 30 Second Sit to Stand Test is also known as 30 second chair stand test ( 30CST), is for testing leg strength and endurance in older adults.

  After 3 days

• Arm curl field test

  The Arm Curl Fitness Test for upper body strength using the bicep curl technique, a test designed of the functional fitness of seniors

  After 3 days

• Stair climbing test

  The stair climb test (also known as stair climb power test) is a clinically relevant, safe, and inexpensive field-based assessment of lower body strength, power, and physical function for older adults

  After 3 days

Secondary Outcomes (1)

• Physical activity scale for elderly (PASE)

  After 3 days

Study Arms (1)

IMF arm

EXPERIMENTAL

The interventional protocol will include healthy older adults age above 60 years. At baseline - all measurements will be collected. After 3 days to one week, as per feasibility, participants will come to the lab again and perform inspiratory Muscle training according to the protocol that tends to induce inspiratory muscle fatigue. (60-80%MIP). Inspiratory resistive loading by starting at 60-80% (MIP) increasing every 10 minutes by 10% then measure Maximum Inspiratory Pressure (MIP), until MIP measurement decrease of more than 10% from baseline will be performed. When report a lower score of MIP and participants could no longer worked out, performed the functional mobility tests and see if there any variation. After the consent of participants an initial evaluation, Anthropometric measurements, Pulmonary function tests, PASE Questionnaire will be taken.

Other: Inspiratory muscle fatigue

Interventions

Inspiratory muscle fatigue OTHER

Muscle training according to the protocol that tends to induce inspiratory muscle fatigue. (60-80% MIP). Inspiratory resistive loading by starting at 60-80% (MIP) increasing every 10 minutes by 10% then measure MIP, until MIP measurement decrease of more than 10% from baseline will be performed. When report a lower score of MIP and participants could no longer worked out, performed the functional mobility tests and see if there any variation.

IMF arm

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults with age 60+ years
• Both male and female participants
• Patients with Forced Expiratory Volume 1/Forced Volume Capacity ratio greater than 80%

You may not qualify if:

• Smokers
• Subjects with a history of cardiovascular, respiratory, or neuromuscular
• Diseases that can impede test or alter the maximum inspiratory pressure.
• Subjects with cognitive impairment.
• Subjects with low back and musculoskeletal disorders.
• Previous experience in respiratory muscle training.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Railway General Hospital

Rawalpindi, Punjab Province, Pakistan

Location

Related Publications (4)

• Seixas MB, Almeida LB, Trevizan PF, Martinez DG, Laterza MC, Vanderlei LCM, Silva LP. Effects of Inspiratory Muscle Training in Older Adults. Respir Care. 2020 Apr;65(4):535-544. doi: 10.4187/respcare.06945. Epub 2019 Oct 29.

  PMID: 31662444 BACKGROUND

• Giua R, Pedone C, Scarlata S, Carrozzo I, Rossi FF, Valiani V, Incalzi RA. Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients. Rejuvenation Res. 2014 Aug;17(4):366-71. doi: 10.1089/rej.2014.1549.

  PMID: 24749768 BACKGROUND

• Watsford ML, Murphy AJ, Pine MJ. The effects of ageing on respiratory muscle function and performance in older adults. J Sci Med Sport. 2007 Feb;10(1):36-44. doi: 10.1016/j.jsams.2006.05.002. Epub 2006 Jun 30.

  PMID: 16814604 BACKGROUND

• Ferraro FV, Gavin JP, Wainwright T, McConnell A. The effects of 8 weeks of inspiratory muscle training on the balance of healthy older adults: a randomized, double-blind, placebo-controlled study. Physiol Rep. 2019 May;7(9):e14076. doi: 10.14814/phy2.14076.

  PMID: 31074198 BACKGROUND

Study Officials

• Suman Sheraz, PhD*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 31, 2023
• First Posted: April 13, 2023
• Study Start: March 1, 2023
• Primary Completion: May 30, 2023
• Study Completion: July 1, 2023
• Last Updated: July 10, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)