NCT05808413

Brief Summary

While COVID-19 vaccine uptake has generally been high in Canada, with 83.4% of the total population having received the first two doses (i.e., primary series), additional "booster" uptake has been slower, especially among young adults aged 18-39. Throughout the pandemic, young adults have experienced less personal risk from COVID-19 infection and this has led to lower motivation to vaccinate when it is recommended. Achieving high rates of up-to-date vaccine coverage is important in this group to anticipate new variants and waves of infection and changes to recommendations which might include annual or seasonal vaccination. Three video interventions, intended to motivate Canadian young adults to adopt positive intentions toward continued COVID-19 vaccination, will be developed and tested: an informational comparison video, an altruistic video, and an individualistic video. Participants will be 3300 Canadian younger adults who will be randomly assigned to watch these videos. The first arm will only receive the informational video, the second arm the informational and altruistic videos, and the third arm the informational, altruistic, and individualistic videos. All participants will complete a brief online survey before and after viewing the assigned video(s). The goal of the study is to examine the efficacy of altruistic and individualistic messages, beyond informational messages, in increasing intentions for COVID-19 vaccination in this age group.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,567

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 7, 2023

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 11, 2023

Completed
2 months until next milestone

Study Start

First participant enrolled

June 6, 2023

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2023

Completed
Last Updated

November 27, 2023

Status Verified

November 1, 2023

Enrollment Period

2 months

First QC Date

April 7, 2023

Last Update Submit

November 23, 2023

Conditions

Keywords

Vaccine HesitancyVaccine Decision Making

Outcome Measures

Primary Outcomes (1)

  • Vaccine Intentions

    Intentions to receive COVID-19 vaccines as they are continually recommended will be measured using the Precaution Adoption Process Model (PAPM). The PAPM is a stage-based model of health decision-making, and will be adapted to contain the categories: unengaged, undecided, decided to, and decided not to receive recommended COVID-19 vaccines. Participants will provide their stage before and after the intervention has been administered, all within the same survey.

    Pre- and post-intervention, within the same survey. The length of the survey is projected to be about 12 minutes.

Study Arms (3)

Informational Video

ACTIVE COMPARATOR

Participants will watch a 1-minute video detailing the impact vaccination has had on the COVID-19 pandemic, where accurate information on vaccination can be found, and the convenience of vaccination.

Behavioral: Informational Video

Informational + Altruistic Video

EXPERIMENTAL

Participants will first watch the 1-minute informational video before watching an additional 40-second video eliciting altruistic motivations for vaccination. The purpose of this arm is to test whether altruistic messages are efficacious to increase vaccine intentions beyond providing only vaccine information.

Behavioral: Informational VideoBehavioral: Altruistic Video

Informational + Altruistic + Individualistic Video

EXPERIMENTAL

Participants will watch the 1-minute informational video, the 40-second altruistic video, and an additional 40-second video eliciting individualistic motivations for vaccination. This arm will be used to test if combined altruistic and individualistic messages provide a greater effect than providing only vaccine information.

Behavioral: Informational VideoBehavioral: Altruistic VideoBehavioral: Individualistic Video

Interventions

This video emphasizes that vaccination against COVID-19 continues to be important, highlights the importance of seeking accurate information, and provides statistics about the estimated number of lives saved by vaccination and reported adverse events following vaccination in Canada.

Informational + Altruistic + Individualistic VideoInformational + Altruistic VideoInformational Video

This video presents a vignette about a young adult woman who has many social interactions during her daily life. It shows that her decision to stay up-to-date on COVID-19 vaccination could help to protect those people she comes into contact with, who may be at greater risk from COVID-19 infection. Statistics are used to show that up to one-in-four people in Canada have underlying conditions that make them more vulnerable to COVID-19, and to quantify the number of surgeries that were delayed by pandemic-related disruptions.

Informational + Altruistic + Individualistic VideoInformational + Altruistic Video

This video presents a vignette about a young adult man who is very health-conscious. He is unsure about staying up-to-date on COVID-19 vaccination until he learns that COVID-19 infection can have serious and disruptive consequences even if someone is younger. Statistics are used to quantify the increased risk of severe symptoms in young adults who are not up-to-date on vaccination.

Informational + Altruistic + Individualistic Video

Eligibility Criteria

Age18 Years - 39 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Residing within Canada
  • Aged between 18 and 39.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Lady Davis Insitutute for Medical Research

Montreal, Quebec, H3T 1E2, Canada

Location

Related Publications (5)

  • Zhu P, Tatar O, Griffin-Mathieu G, Perez S, Haward B, Zimet G, Tunis M, Dube E, Rosberger Z. The Efficacy of a Brief, Altruism-Eliciting Video Intervention in Enhancing COVID-19 Vaccination Intentions Among a Population-Based Sample of Younger Adults: Randomized Controlled Trial. JMIR Public Health Surveill. 2022 May 30;8(5):e37328. doi: 10.2196/37328.

    PMID: 35544437BACKGROUND
  • Zhu P, Tatar O, Haward B, Steck V, Griffin-Mathieu G, Perez S, Dube E, Zimet G, Rosberger Z. Examining an Altruism-Eliciting Video Intervention to Increase COVID-19 Vaccine Intentions in Younger Adults: A Qualitative Assessment Using the Realistic Evaluation Framework. Vaccines (Basel). 2023 Mar 11;11(3):628. doi: 10.3390/vaccines11030628.

    PMID: 36992212BACKGROUND
  • Brewer NT, Chapman GB, Rothman AJ, Leask J, Kempe A. Increasing Vaccination: Putting Psychological Science Into Action. Psychol Sci Public Interest. 2017 Dec;18(3):149-207. doi: 10.1177/1529100618760521.

    PMID: 29611455BACKGROUND
  • Yuan S, Chu H. Vaccine for yourself, your community, or your country? Examining audiences' response to distance framing of COVID-19 vaccine messages. Patient Educ Couns. 2022 Feb;105(2):284-289. doi: 10.1016/j.pec.2021.08.019. Epub 2021 Aug 25.

    PMID: 34479746BACKGROUND
  • Reifferscheid L, Lee JSW, MacDonald NE, Sadarangani M, Assi A, Lemaire-Paquette S, MacDonald SE. Transition to endemic: acceptance of additional COVID-19 vaccine doses among Canadian adults in a national cross-sectional survey. BMC Public Health. 2022 Sep 14;22(1):1745. doi: 10.1186/s12889-022-14025-8.

    PMID: 36104675BACKGROUND

MeSH Terms

Conditions

Vaccination RefusalCOVID-19Vaccination Hesitancy

Condition Hierarchy (Ancestors)

Treatment RefusalTreatment Adherence and ComplianceHealth BehaviorBehaviorPneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Zeev Rosberger, PhD

    Lady Davis Institute for Medical Research of the Jewish General Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Masking Details
The survey company, Dynata, will collect all data and manage group assignments. Participants' intervention group assignments will be unavailable to the investigator.
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Participants will be randomly assigned to one of: 1) a control video, 2) the control + an altruistic video, or 3) the control + altruistic video + individualistic video. A 1:1:1 randomization ratio will be used.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Investigator

Study Record Dates

First Submitted

April 7, 2023

First Posted

April 11, 2023

Study Start

June 6, 2023

Primary Completion

August 1, 2023

Study Completion

August 1, 2023

Last Updated

November 27, 2023

Record last verified: 2023-11

Data Sharing

IPD Sharing
Will not share

The consent form, data collection method, and organizational policy means only aggregated data will be shared with other researchers.

Locations