Exercise Induced Plasma Volume Expansion Lowers Cardiovascular Strain

NCT05800808 | Completed

• 1 other identifier: Plasma Volume and Hypoxia
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study was to better understand the impact of increased plasma volume on later exercise in hypoxia. Investigators examined young, healthy, males who regularly participated in aerobic exercise. Investigators first measured participant's response to exercise in hypoxia (simulated \~7,500 feet above sea level). The investigators then had participants either 1) undergo 1 bout of high intensity interval exercise or 2) undergo 1 bout of moderate, continuous exercise. 48 hours after the exercise, participants were again examined in hypoxia.

Conditions

Cardiac Output; Stroke Volume

Keywords

Hypervolemia; high intensity exercise; altitude exposure

Outcome Measures

Primary Outcomes (2)

• Hemoglobin Concentration

  measured through spectroscopy

  through study completion, an average of 4 weeks

• Hematocrit Concentration

  measured through hematocrit reader

  through study completion, an average of 4 weeks

Secondary Outcomes (2)

• Time Trial Time

  through study completion, an average of 4 weeks

• Cardiac Output

  through study completion, an average of 4 weeks

Study Arms (2)

High Intensity Exercise

EXPERIMENTAL

Vigorous cycling

Procedure: High Intensity Intervals

Continuous Moderate Exercise

ACTIVE COMPARATOR

Leisurely cycling

Procedure: Moderate Exercise

Interventions

High Intensity Intervals PROCEDURE

8x4 min cycling bouts at 85% of VO2peak

High Intensity Exercise

Moderate Exercise PROCEDURE

81 minutes of cycling at 50% VO2peak

Continuous Moderate Exercise

Eligibility Criteria

• Age: 18 Years - 38 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males age 18-38
• Exercise at least 3 times/week for at least 30 minutes/day for the past 3 months.

You may not qualify if:

• Frequent hot bath or sauna users
• Resided at altitude greater than 2,500 meters for \>14 days.
• Cardiovascular or metabolic disease

Sponsors & Collaborators

• California Baptist University: lead
• High Point University: collaborator
• United States Army Research Institute of Environmental Medicine: collaborator

Study Sites (1)

California Baptist University

Riverside, California, 92504-3206, United States

Location

Related Publications (16)

• Alexander JK, Hartley LH, Modelski M, Grover RF. Reduction of stroke volume during exercise in man following ascent to 3,100 m altitude. J Appl Physiol. 1967 Dec;23(6):849-58. doi: 10.1152/jappl.1967.23.6.849. No abstract available.

  PMID: 6065055 BACKGROUND

• Beidleman BA, Staab JE, Muza SR, Sawka MN. Quantitative model of hematologic and plasma volume responses after ascent and acclimation to moderate to high altitudes. Am J Physiol Regul Integr Comp Physiol. 2017 Feb 1;312(2):R265-R272. doi: 10.1152/ajpregu.00225.2016. Epub 2016 Dec 30.

  PMID: 28039191 BACKGROUND

• Berger NJ, Campbell IT, Wilkerson DP, Jones AM. Influence of acute plasma volume expansion on VO2 kinetics, VO2 peak, and performance during high-intensity cycle exercise. J Appl Physiol (1985). 2006 Sep;101(3):707-14. doi: 10.1152/japplphysiol.00154.2006. Epub 2006 May 11.

  PMID: 16690793 BACKGROUND

• Brothers MD, Wilber RL, Byrnes WC. Physical fitness and hematological changes during acclimatization to moderate altitude: a retrospective study. High Alt Med Biol. 2007 Fall;8(3):213-24. doi: 10.1089/ham.2007.8308.

  PMID: 17824822 BACKGROUND

• Chapman RF, Laymon AS, Levine BD. Timing of arrival and pre-acclimatization strategies for the endurance athlete competing at moderate to high altitudes. High Alt Med Biol. 2013 Dec;14(4):319-24. doi: 10.1089/ham.2013.1022.

  PMID: 24377334 BACKGROUND

• Chapman RF, Stager JM, Tanner DA, Stray-Gundersen J, Levine BD. Impairment of 3000-m run time at altitude is influenced by arterial oxyhemoglobin saturation. Med Sci Sports Exerc. 2011 Sep;43(9):1649-56. doi: 10.1249/MSS.0b013e318211bf45.

  PMID: 21311361 BACKGROUND

• Chapman RF, Stickford JL, Levine BD. Altitude training considerations for the winter sport athlete. Exp Physiol. 2010 Mar;95(3):411-21. doi: 10.1113/expphysiol.2009.050377. Epub 2009 Oct 16.

  PMID: 19837773 BACKGROUND

• Coles MG, Luetkemeier MJ. Sodium-facilitated hypervolemia, endurance performance, and thermoregulation. Int J Sports Med. 2005 Apr;26(3):182-7. doi: 10.1055/s-2004-820989.

  PMID: 15776333 BACKGROUND

• Coyle EF, Hopper MK, Coggan AR. Maximal oxygen uptake relative to plasma volume expansion. Int J Sports Med. 1990 Apr;11(2):116-9. doi: 10.1055/s-2007-1024774.

  PMID: 1692570 BACKGROUND

• Fortney SM, Wenger CB, Bove JR, Nadel ER. Effect of blood volume on forearm venous and cardiac stroke volume during exercise. J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):884-90. doi: 10.1152/jappl.1983.55.3.884.

  PMID: 6629925 BACKGROUND

• Fulco CS, Muza SR, Beidleman BA, Demes R, Staab JE, Jones JE, Cymerman A. Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude. Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R428-36. doi: 10.1152/ajpregu.00633.2010. Epub 2010 Dec 1.

  PMID: 21123763 BACKGROUND

• Fulco CS, Rock PB, Cymerman A. Maximal and submaximal exercise performance at altitude. Aviat Space Environ Med. 1998 Aug;69(8):793-801.

  PMID: 9715971 BACKGROUND

• Gillen CM, Lee R, Mack GW, Tomaselli CM, Nishiyasu T, Nadel ER. Plasma volume expansion in humans after a single intense exercise protocol. J Appl Physiol (1985). 1991 Nov;71(5):1914-20. doi: 10.1152/jappl.1991.71.5.1914.

  PMID: 1761491 BACKGROUND

• Gillen CM, Nishiyasu T, Langhans G, Weseman C, Mack GW, Nadel ER. Cardiovascular and renal function during exercise-induced blood volume expansion in men. J Appl Physiol (1985). 1994 Jun;76(6):2602-10. doi: 10.1152/jappl.1994.76.6.2602.

  PMID: 7928889 BACKGROUND

• Greenleaf JE, Looft-Wilson R, Wisherd JL, Jackson CG, Fung PP, Ertl AC, Barnes PR, Jensen CD, Whittam JH. Hypervolemia in men from fluid ingestion at rest and during exercise. Aviat Space Environ Med. 1998 Apr;69(4):374-86.

  PMID: 9561285 BACKGROUND

• Gorini Pereira F, Greenfield AM, Kuennen M, Gillum TL. Exercise induced plasma volume expansion lowers cardiovascular strain during 15-km cycling time-trial in acute normobaric hypoxia. PLoS One. 2024 Feb 2;19(2):e0297553. doi: 10.1371/journal.pone.0297553. eCollection 2024.

  PMID: 38306343 DERIVED

MeSH Terms

Conditions

Edema

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 28, 2023
• First Posted: April 6, 2023
• Study Start: January 15, 2019
• Primary Completion: December 15, 2019
• Study Completion: December 8, 2022
• Last Updated: April 6, 2023

Record last verified: 2023-04

Locations

US (1)