Study on Hospitalization of Children With Bronchial Asthma
1 other identifier
observational
470
1 country
1
Brief Summary
Bronchial asthma is the most common chronic respiratory disease in children. At present, more attention has been paid to the treatment of airway inflammation and smooth muscle spasm, while the related research on the risk factors of asthma attack, mucus plug formation and its effect on asthma has been ignored. This study was a retrospective study. Children hospitalized for acute exacerbation of asthma from 2016 to 2021 were selected as the research objects. The clinical manifestations, bronchoscopy results and lung CT results of children hospitalized for acute exacerbation of asthma were summarized. To analyze the risk factors of acute exacerbation, clinical characteristics, risk factors of mucus plug formation in hospitalized children with asthma, and the safety and efficacy of flexible bronchoscopy in the diagnosis and treatment of hospitalized children with asthma. The discharged children were investigated by written or online questionnaires to understand the acute attack of asthma, control level, compliance, appliability of the China Children's Asthma Action Plan, family management and medical utilization of children with asthma after discharge.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2023
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 1, 2023
CompletedFirst Posted
Study publicly available on registry
April 5, 2023
CompletedStudy Start
First participant enrolled
July 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2025
CompletedOctober 17, 2023
October 1, 2023
1.8 years
March 1, 2023
October 15, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Clinical characteristics of hospitalized children with acute asthma attack
clinical characteristics includes: age, sex, asthma severity (mild, severe), asthma inducing factors(infection, allergy, smoke, excerise) and hospitalization expenses
From January 2016 to December 2021
Influencing factors of acute attack severity in hospitalized children with asthma
age, sex, allergy history, birth history, family history, the severity of asthma exacerbation, lung function and lung computed tomography
From January 2016 to December 2021
Risk factors for acute exacerbation of asthma with respiratory failure in children
The proportion of children hospitalized for acute exacerbation of asthma with respiratory failure, and age, sex, allergy history（with or without）, family history (asthma, atopic dermatitis,rhinitis and allergy), the severity of asthma exacerbation(mild, severe), lung function (normal, abnormal) and lung computed tomography(normal, abnormal)
From January 2016 to December 2021
Risk factors for mucus plug formation in hospitalized children with asthma exacerbation
The results of lung CT examination in children with asthma(normal, abnormal), the incidence of mucus plug in hospitalized children with asthma
From January 2016 to December 2021
Identification of mucus plugs in hospitalized children with asthma
Using mucus scoring system which was based on bronchopulmonary segmental anatomy identified mucus plugs in hospitalized children with asthma. Each bronchopulmonary segment was given a score of 1 (mucus plug present) or 0 (mucus plug absent). The segment scores of each lobe were summed to generate a total mucus score for both lungs, yielding a mucus score ranging from 0-20.
From January 2016 to December 2021
Eligibility Criteria
Children admitted with acute episodes of asthma
You may qualify if:
- Children admitted with acute episodes of asthma between January 2016 and December 2021
You may not qualify if:
- Basic information is incomplete
- Lack of relevant information on diagnosis and treatment after admission
- Those who disagree with the telephone follow-up
- Basic diseases such as heart, liver and kidney
- Children with primary or secondary immunodeficiency, genetic metabolic diseases, tumors, or after organ or hematopoietic stem cell transplantation
- Active pulmonary tuberculosis and children with a history of asthma who are hospitalized for other reasons
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Beijing Children's Hospital affiliated to Capital Medical University
Beijing, China
Related Publications (1)
Han P, Yin J, Zou H, Jiao A, Liu Y, Shen K. Exploring the types of airway inflammation in hospitalized children with asthma. BMC Pediatr. 2025 May 7;25(1):359. doi: 10.1186/s12887-025-05596-7.
PMID: 40329237DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
kunling shen, doctor
Beijing Children's Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- professor
Study Record Dates
First Submitted
March 1, 2023
First Posted
April 5, 2023
Study Start
July 1, 2023
Primary Completion
April 1, 2025
Study Completion
April 1, 2025
Last Updated
October 17, 2023
Record last verified: 2023-10
Data Sharing
- IPD Sharing
- Will not share