NCT05796674

Brief Summary

The purpose of this study is to provide real world evidence (RWE) on the performance of the Clareon ultraviolet absorbing (UVA) intraocular lenses (IOLs) to support the overall body of evidence on the Clareon IOL family.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,090

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2023

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 20, 2023

Completed
14 days until next milestone

First Posted

Study publicly available on registry

April 3, 2023

Completed
5 months until next milestone

Study Start

First participant enrolled

August 18, 2023

Completed
25 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 12, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 12, 2023

Completed
Last Updated

October 18, 2023

Status Verified

October 1, 2023

Enrollment Period

25 days

First QC Date

March 20, 2023

Last Update Submit

October 16, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Monocular Best Corrected Distance Visual Acuity (BCDVA) at Postoperative Visit

    The database will be reviewed for assessments of monocular (by-eye) best corrected distance visual acuity at the first postoperative visit. The first postoperative visit will be defined as the visit which occurred approximately 28 days or later from the operative visit during which time the IOL remained implanted in the eye and an eye exam was performed.

    Month 1 postoperative

Study Arms (1)

Clareon UVA IOL

Eyes that underwent cataract surgery and received a Clareon UVA IOL with the use of the WaveTec Optiwave Refractive Analysis (ORA) System

Device: Clareon UVA IOLDevice: WaveTec Optiwave Refractive Analysis (ORA) SystemProcedure: Cataract surgery

Interventions

Clareon UVA IOL placed in the capsular bag in the posterior chamber of the eye during cataract surgery to replace the natural crystalline lens. Models CC60WF and CCA0T0 are indicated for the visual correction of aphakia. Models CCW0T3, CCW0T4, CCW0T5, and CCW0T6 are indicated for the visual correction of aphakia and preexisting corneal astigmatism.

Also known as: Models CC60WF, CCW0T3, CCW0T4, CCW0T5, CCW0T6, CCA0T0
Clareon UVA IOL

Intra-operative system used during refractive cataract surgery to capture wavefront images of the patient's eye for the purpose of optimizing IOL implantation

Clareon UVA IOL

Cataract extraction by phacoemulsification, followed by implantation with a Clareon UVA IOL

Clareon UVA IOL

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

A description of the population from which the groups or cohorts will be selected (for example, primary care clinic, community sample, residents of a certain town). Information is entered into the WaveTec AnalyzOR Database by medical professionals post cataract surgery.

Data Selection Criteria (eyes): * Must have undergone cataract extraction by phacoemulsification with implantation of a Clareon UVA IOL (CC60WF, CCW0T3, CCW0T4, CCW0T5, CCW0T6, or CCA0T0) using the WaveTec ORA System. * Must have a BCDVA in the WaveTec AnalyzOR Database from ≥ 10 days after surgery. * Predicted residual refractive error spherical equivalent (SE) ≤ 0.75 D.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

Alcon Research, LLC

Fort Worth, Texas, 76134, United States

Location

MeSH Terms

Conditions

AphakiaAstigmatism

Interventions

Drug Delivery SystemsCataract Extraction

Condition Hierarchy (Ancestors)

Lens DiseasesEye DiseasesRefractive Errors

Intervention Hierarchy (Ancestors)

Drug TherapyTherapeuticsRefractive Surgical ProceduresOphthalmologic Surgical ProceduresSurgical Procedures, Operative

Study Officials

  • Clinical Lead, Surgical

    Alcon Research, LLC

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 20, 2023

First Posted

April 3, 2023

Study Start

August 18, 2023

Primary Completion

September 12, 2023

Study Completion

September 12, 2023

Last Updated

October 18, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will not share

Locations