NCT05794854

Brief Summary

Spot reduction, referring to local body fat reduction, pertains to subcutaneous adipose tissue utilization from specific body parts during exercise. Its existence has been keenly debated, although generally accepted not to occur during exercise. However, it is based on not only equivocal data - commonly the training protocol typically applied is based on strength rather than endurance training. The investigators sought to test this assumption by utilizing endurance based exercise controlling for energy expenditure and using dual x-ray absorptiometric measures to assess body composition before and after training.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable healthy

Timeline
Completed

Started Aug 2005

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2005

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2006

Completed
16.9 years until next milestone

First Submitted

Initial submission to the registry

March 20, 2023

Completed
14 days until next milestone

First Posted

Study publicly available on registry

April 3, 2023

Completed
Last Updated

April 3, 2023

Status Verified

March 1, 2023

Enrollment Period

9 months

First QC Date

March 20, 2023

Last Update Submit

March 31, 2023

Conditions

Keywords

endurance exercisesubcutaneous tissue utilization

Outcome Measures

Primary Outcomes (1)

  • Trunk fat mass change

    Fat mass located in trunk (g) measured by dual-energy x-ray absorptiometry

    Change from pre (baseline) to post test (after 10 weeks)

Secondary Outcomes (7)

  • Lower extremity fat mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • Upper extremity fat mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • Total fat mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • Body weight change

    Change from pre (baseline) to post test (after 10 weeks)

  • Body mass index change

    Change from pre (baseline) to post test (after 10 weeks)

  • +2 more secondary outcomes

Other Outcomes (6)

  • Trunk lean mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • Lower extremity lean mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • Upper extremity lean mass change

    Change from pre (baseline) to post test (after 10 weeks)

  • +3 more other outcomes

Study Arms (2)

abdominal aerobic endurance exercise

EXPERIMENTAL

Subjects were combining treadmill running at 70% HRmax (27 minutes) with 4x4minutes (30-40% maximal strength, 1RM) of torso rotation and abdominal crunches (57 minutes), 4 d per wk for 10 weeks

Other: Abdominal aerobic endurance exercise

Control group

ACTIVE COMPARATOR

Subjects performed only treadmill running (45 minutes) at 70% HRmax for 4 d per week for 10 weeks.

Other: Control training intervention

Interventions

Subjects combined treadmill running at 70% HRmax (27 minutes) with 4x4minutes (30-40% maximal strength, 1RM) of torso rotation and abdominal crunches (57 minutes), 4 days per wk for 10 weeks

abdominal aerobic endurance exercise

Subjects performed treadmill running (45 minutes) at 70% HRmax 4 days per week for 10 weeks

Control group

Eligibility Criteria

Age30 Years - 60 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • males
  • ≥ 30 years old
  • classified as overweight (Body mass index ≥ 25 kg ∙ m-2)
  • not participating in regular physical training

You may not qualify if:

  • \< 30 years old
  • Body mass index \< 25 kg ∙ m-2
  • participating in regular physical training

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Assessor of dual x-ray absorptiometry results was blinded to group allocation
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 20, 2023

First Posted

April 3, 2023

Study Start

August 1, 2005

Primary Completion

May 1, 2006

Study Completion

May 1, 2006

Last Updated

April 3, 2023

Record last verified: 2023-03

Data Sharing

IPD Sharing
Will not share