Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane

NCT05791123 | Completed DMC

• 1 other identifier: REC-FDBSU/05012023-03/ER
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

fourteen patients requiring extraction of one posterior tooth with lost buccal bone (\>50%) confirmed preoperatively by Cone-beam computed tomography (CBCT) scans. Extraction sockets were filled with minced PRF clots mixed with the bovine xenograft and covered by PRF membranes to seal the extraction sockets. (CBCT) scans, performed before tooth extraction and after 6 months, were used to assess vertical and horizontal bone changes.

Conditions

Bone Regeneration

Outcome Measures

Primary Outcomes (1)

• the change in alveolar bone width and height in mm using CBCT scans.

  Cone Beam Computed Tomography were taken for each patients before tooth extraction and after 6 months, which were used to assess alveolar ridge changes in width and length in mm.

  6 months

Study Arms (1)

a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket

EXPERIMENTAL

Procedure: a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket

Interventions

a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket PROCEDURE

Extraction sockets were filled with minced PRF clots mixed with the bovine xenograft and covered by PRF membranes to seal the extraction sockets.

a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients required implant treatment after tooth extraction
• Age group ranged from 20-60 years old.
• Patients could undergo the treatment under local anesthesia.
• Loss of buccal bone (\>50%) confirmed by preoperative cone beam computed tomography (CBCT).
• Presence of other socket walls; mesial, distal and lingual walls.
• Tooth needed to be extracted in upper or lower posterior regions

You may not qualify if:

• Uncontrolled diabetic diseases.
• Uncontrolled hypertension, or hepatic and renal disorders.
• Any systemic diseases associated with bone metabolism.

Sponsors & Collaborators

• Future University in Egypt: lead

Study Sites (1)

Future University in Egypt

Cairo, Egypt

Location

Related Publications (1)

• Elbanna RM, Abdelaziz MS, Alameldeen HE. Augmentation of single tooth extraction socket with deficient buccal walls using bovine xenograft with platelet-rich fibrin membrane. BMC Oral Health. 2023 Nov 17;23(1):874. doi: 10.1186/s12903-023-03554-2.

  PMID: 37978487 DERIVED

MeSH Terms

Interventions

Prolactin-Releasing Hormone

Intervention Hierarchy (Ancestors)

Hypothalamic Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Neuropeptides; Peptides; Amino Acids, Peptides, and Proteins; Nerve Tissue Proteins; Proteins

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of Prosthodontics

Study Record Dates

• First Submitted: March 8, 2023
• First Posted: March 30, 2023
• Study Start: July 15, 2018
• Primary Completion: February 20, 2023
• Study Completion: March 5, 2023
• Last Updated: March 30, 2023

Record last verified: 2023-03

Locations

EG (1)