The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study

NCT05788224 | Unknown DMC

• 1 other identifier: BDS02
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer. The final endpoint is to report morbidity and mortality in this group of frail individuals according to the shift of incidence of colorectal cancer in geriatric patients, over 2 periods: before the COVID pandemic outbreak (11th March 2020) and after the 11th March, during the ongoing pandemic.

Conditions

Advanced Colorectal Cancer in Elderly Patient

Keywords

elderly; oldest; colorectal cancer; perforation; bleeding; obstruction; emergency; surgery; laparotomy; laparoscopy; futility; frailty

Outcome Measures

Primary Outcomes (1)

• mortality and morbidity correlated with the management of older (=>75 years old) patients admitted to emergency department with a complicated colorectal cancer

  through study completion, an average of 1 year

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All older (aged 75 years old and over) patients who were admitted to the surgical department with acute abdominal pain due to a complication of colorectal cancer.

You may qualify if:

• Patients aged 75 years old and over;
• Admission to the emergency department with acute abdominal pain;
• Diagnosis of obstructed and/or perforated colorectal cancer.

You may not qualify if:

• Patients aged\< 75 years old;
• Patients aged \>=75 years old admitted with acute abdomen, not due to complicated colorectal cancer.

Sponsors & Collaborators

• Poissy-Saint Germain Hospital: lead
• Fausto Catena: collaborator
• World Society of Emergency Surgery: collaborator

Study Sites (1)

World Society of Emergency Surgery

Paris, 75016, France

RECRUITING

Related Publications (1)

• DE Simone B, Abu-Zidan FM, Podda M, Pellino G, Sartelli M, Coccolini F, DI Saverio S, Biffl WL, Kaafarani HM, Moore EE, Dhesi JK, Moug S, Ansaloni L, Avenia N, Catena F; CO-OLDER Collaborators. The management of complicated colorectal cancer in older patients in a global perspective after COVID-19: the CO-OLDER WSES project. Minerva Surg. 2024 Jun;79(3):273-285. doi: 10.23736/S2724-5691.23.10165-1.

  PMID: 38847766 DERIVED

MeSH Terms

Conditions

Colorectal Neoplasms; Hemorrhage; Bites and Stings; Emergencies; Frailty

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Disease Attributes

Study Officials

• Belinda De Simone, MD

  World Society of Emergency Surgery

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Belinda De Simone, MD

CONTACT

+33665787872; desimone.belinda@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 14, 2023
• First Posted: March 28, 2023
• Study Start: May 1, 2022
• Primary Completion: September 30, 2023
• Study Completion: January 2, 2024
• Last Updated: May 24, 2023

Record last verified: 2023-05

Locations

FR (1)