NCT05781529|CompletedDMC
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Sponsor study identifier
interventional
36
1 country
2
Study Start
March 6, 2019
Actual (reported)Primary Completion
July 16, 2021
Actual (reported)Study Completion
August 31, 2021
Actual (reported)Thirty-six patients (19 females and 17 males) that required implant placement in esthetic zone participated in this study and were blindly allocated 12 patients per group, all patients had ARP either with I-PRF with xenograft, HA with xenograft or xenograft alone, the sockets were sealed with free gingival graft harvested from the palate.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 31, 2021
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 6, 2019
Actual (reported)July 16, 2021
Actual (reported)August 31, 2021
Actual (reported)February 28, 2023
Actual (reported)March 23, 2023
Actual (reported)Radiographic bone width
Cone beam CT (CBCT) were obtained preoperatively and 4 months postoperatively. The radiographs were analyzed using One- Viewer viewing software (iCATVision). The buccolingual width was measured into different levels. At the bone crest (A), 3mm from the bone crest (B) and 6 mm from the bone crest (C). For standardization in the sagittal slice, the axial plane was adjusted to pass through the cemento enamel junction (CEJ) of the adjacent teeth. On the axial slice, the mesiodistal dimension from the distal surface to mesial surface of the adjeceent teeth was measured. The coronal plane was adjusted to be pass through the middle of the distance in order to be perpendicular to both buccal and lingual cortices. Measurement were all performed on the coronal slices. In addition, fusion was done by superimposing preoperative and 4 months CBCT in all groups.
4 months postoperative
histological and histomorphometric assessment
4 months postoperative
Injectable platelets rich fibrin was prepared where 10 ml of patient venous blood was centrifuged without anti-coagulants (plain plastic glass-coated) at 700 rpm speed for only 3 minutes, xenograft was mixed with I-PRF to make sticky bone, sticky bone was placed into extraction socket till the socket was fully filled up to the gingival margin
Hyaluronic acid (HA) syringe containing 1 mL of cross-linked hyaluronic at a concentration of 20 mg/ml in a saline phosphate buffer solution at sterilized content was used. HA was mixed with particulate xenograft 1:10 ratio to form a putty consistency for condensation and was placed into extraction socket till the socket was fully filled up to the gingival margin
Injectable platelets rich fibrin is added to xenograft for alveolar ridge augmentation in order to preserve bone and decrease bone resorption
Doaa Adel Salah Khattab
Cairo, Abbassia, 11566, Egypt
Doaa Khattab
Cairo, Abbassia, 11566, Egypt
Abaza G, Abdel Gaber HK, Afifi NS, Adel-Khattab D. Injectable platelet rich fibrin versus hyaluronic acid with bovine derived xenograft for alveolar ridge preservation. A randomized controlled clinical trial with histomorphometric analysis. Clin Implant Dent Relat Res. 2024 Feb;26(1):88-102. doi: 10.1111/cid.13289. Epub 2023 Oct 31.
36 participants (actual enrollment reported by the registry).
First Submitted
February 28, 2023
First Posted
March 23, 2023
Study Start
March 6, 2019
Actual (reported)Modified Ridge Splitting Technique Using Autogenous Bone Blocks (MRS)
Xenograft was mixed with saline, placed in extraction socket till the socket is fully filled up to the gingival margin
Hyaluronic is added to xenograft for alveolar ridge augmentation in order to preserve bone and decrease bone resorption
Xenograft is added alone as a active compatator
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Primary Completion
July 16, 2021
Actual (reported)Study Completion
August 31, 2021
Actual (reported)Last Updated
March 23, 2023
Record last verified: 2023-03
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Source: ClinicalTrials.gov.
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