Visual Mode Switching in Color Perception

NCT05779228 | Withdrawn

• 1 other identifier: STUDY00002354
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.

Conditions

Perception of Things Changing Color; Adaptive Behavior

Keywords

Visual Perception; Visual Adaptation; Color Perception

Outcome Measures

Primary Outcomes (3)

• Change in unique yellow settings

  This is a standard psychophysical measure referenced in 100s of papers. Participants adjust a patch of color until it appears neither red nor green and this color is reported in standard colorimetric coordinates (e.g. CIE).

  Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.

• Change in BOLD functional MRI activity

  Neural activation will be measured with functional MRI which will be used to measure BOLD activity with standard methods, and reported as percent change from rest, a standard measure, for each voxel in the brain.

  Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.

• Change in EEG activity

  Neural activity will be measured with electroencephelography using standard techniques and will be reported as voltage changes over time for each electrode in a standard configuration.

  Change will be assessed over the entire study, by comparing a pre-test the day before the intevention (which lasts 5 days) to a post-test the day after the intervention.

Study Arms (6)

Color Contrast

EXPERIMENTAL

Test patch is surrounded spatially by different colors

Behavioral: Mode Switching Training

Color Adaptation

EXPERIMENTAL

Test patch is surrounded temporally (preceded) by different colors

Behavioral: Mode Switching Training

Neuroimaging

EXPERIMENTAL

Functional MRI and Electroencephelography data are acquired for multiple test colors

Behavioral: Mode Switching Training

Red Room

EXPERIMENTAL

Participants are tested in a red-illuminated room

Behavioral: Mode Switching Training

Dark Room

EXPERIMENTAL

Participants are tested in a completely darkened room

Behavioral: Mode Switching Training

Gradual Change

EXPERIMENTAL

Participants view a gradual change in tint, presented on a head-mounted display

Behavioral: Mode Switching Training

Interventions

Mode Switching Training BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Color Adaptation; Color Contrast; Dark Room; Gradual Change; Neuroimaging; Red Room

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Normal or corrected to normal vision by contact lenses
• No known visual disorders
• Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)

You may not qualify if:

• Abnormal color vision

Sponsors & Collaborators

• University of Minnesota: lead

Study Sites (1)

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

Related Publications (1)

• Li Y, Tregillus KE, Luo Q, Engel SA. Visual mode switching learned through repeated adaptation to color. Elife. 2020 Dec 15;9:e61179. doi: 10.7554/eLife.61179.

  PMID: 33320093 RESULT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The interventional study type is correct. The investigative team is giving all subjects a treatment- behavioral training in visual mode switching- and measuring effects of that treatment, by comparing measures made before to measures made after the treatment. Thus, this is a within-subjects, repeated measures experimental design. The experimenters have 6 different measurements they are using this design in different groups of subjects run in parallel, all examining different effects of the same treatment. . This is why parallel study model is appropriate. These parallel groups with different measurements, but same treatment, are the arms of the study.

Study Record Dates

• First Submitted: January 20, 2023
• First Posted: March 22, 2023
• Study Start: January 1, 2026
• Primary Completion (Estimated): February 4, 2031
• Study Completion (Estimated): February 4, 2032
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ANALYTIC CODE
• Time Frame: Data will be available for at least 10 years, starting at publication date or end of the study.
• Access Criteria: Publicly accessible

Locations

US (1)