LA PrEP Impact and Cost-effectiveness (TEAMS)
Epidemiological Impact and Cost-effectiveness of Long-acting Antiretrovirals for Pre-exposure Prophylaxis Among Key Populations in Thailand
1 other identifier
interventional
10,720
1 country
12
Brief Summary
This study will have three components:
- 1.Discrete choice experiments
- 2.Analysis of routine service data
- 3.Impact and cost-effectiveness analyses using results from 1 and 2
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable hiv
Started Mar 2022
Longer than P75 for not_applicable hiv
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 15, 2022
CompletedFirst Submitted
Initial submission to the registry
February 22, 2023
CompletedFirst Posted
Study publicly available on registry
March 17, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 15, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 30, 2028
March 18, 2026
March 1, 2026
4.8 years
February 22, 2023
March 16, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
The epidemiological impact of long-acting antiretrovirals for HIV prevention among Thai MSM and TGW at risk of HIV infection
Epidemiological impact analyses will compare a current scenario in which PrEP is only available as an oral formulation to a scenario in which long-acting PrEP is also available.
12 months
The cost-effectiveness of long-acting antiretrovirals for HIV prevention among Thai MSM and TGW at risk of HIV infection
The cost-effectiveness analysis will be based on previous HIV transmission models published by the Erasmus Medical Centre
12 months
Secondary Outcomes (3)
Proportion of MSM and TGW indicating uptake of PrEP in hypothetic scenarios, impact of sociodemographic and behavioral characteristics on projected uptake
18 months
Preferred PrEP modalities among Thai MSM and TGW, trade-off of different PrEP attributes
18 months
Patterns of PrEP use
18 months
Study Arms (1)
(PHASE I) Attributes identification
EXPERIMENTALTo identify attributes of importance for our research question and assign possible levels to these attributes, a combination of literature review and qualitative approaches will be conducted
Interventions
In-depth interviews (IDI) 20 MSM,20 TGW, current, previous PrEP users will assess which attributes are relevant each population. Posters will be used to recruit for IDIs. Self-reported HIV-negative who either report interest in current or past PrEP use will be eligible to participate in IDI. IDI will be conducted by a study by in-person, on-line interviews.
Focus group discussion (FGD) will discuss a interested information from IDIs. IDIs will be informed, invited to a FGD. FGD recruit 6-10 IDI. 10 random number will be generated using statistical if more 10 individuals show interest in participating in a FGD. If there are less than 6 accepted participants for a FGD, the backup list or new participant will be invited. Study will perform FGD by in-person, on-line conference. Data obtained during a process will be used to create a list of attributes for each population, their levels to include in the choice tasks, ensuring that a choices are plausible, exchangeable.
Eligibility Criteria
You may qualify if:
- Minimum age of 18 years
- Individual assigned male at birth reporting sex with men in the past 12 months
- Self-reported HIV-negative MSM and TGW who either report interest in PrEP use, current PrEP use, or past PrEP use
- Permit audio recording during the interview and/or discussion.
You may not qualify if:
- Not willing to participate in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (12)
Rainbow Sky Association of Thailand (RSAT)
Bangkok, Bangkapi, 10240, Thailand
The Service Workers In Group Foundation (SWING)
Bangkok, Building 3, Patpong, Surawong Road, 10500, Thailand
The Service Workers In Group Foundation (SWING)
Bang Lamung, Changwat Chon Buri, 20150, Thailand
Rainbow Sky Association of Thailand (RSAT)
Chon Buri, Changwat Chon Buri, 20000, Thailand
Rainbow Sky Association of Thailand (RSAT)
Hat Yai, Changwat Songkhla, 90110, Thailand
Tangerine Clinic
Bangkok, Pathumwan, 10330, Thailand
The Service Workers In Group Foundation (SWING)
Bangkok, Phay Thai, 10400, Thailand
CAREMAT
Chiang Mai, 50200, Thailand
Mplus Foundation
Chiang Mai, 50200, Thailand
Mplus Foundation
Chiang Rai, 57000, Thailand
Mplus Foundation
Phitsanulok, 65000, Thailand
Rainbow Sky Association of Thailand (RSAT)
Ubon Ratchathani, 34000, Thailand
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nittaya Phanuphak, MD,PhD.
INSTITUTE OF HIV RESEARCH AND INNOVATION FOUNDATION
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 22, 2023
First Posted
March 17, 2023
Study Start
March 15, 2022
Primary Completion (Estimated)
December 15, 2026
Study Completion (Estimated)
December 30, 2028
Last Updated
March 18, 2026
Record last verified: 2026-03