NCT05773404

Brief Summary

Introduction: The prevalence of hamstring injuries in football is high, causing an increase in the number of casualties and a high socio-economic cost. Currently there are different treatment protocols for this muscle group, but there are often no comparisons of different types of passive, active and combined therapies, and their potential efficacy, in professional football players. Objectives: To compare the efficacy of three different interventions; passive manual therapy, active therapy based on therapeutic exercise and combined therapy, in relation to hamstring injuries in professional football players. Methodology: A simple Randomised Clinical Trial (RCT) was conducted (NCT04935398). After applying the selection criteria, a sample of 66 professional football players was obtained. They were divided into 3 intervention groups (A, B and C) with 22 participants in each group and were given passive manual therapy, active therapy (exercise) and combined therapy (sum of the above). The corresponding tests and questionnaires were evaluated to obtain data on hamstring flexibility and hip range of movement at three time periods: pre, post and post2.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
66

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2023

Completed
5 days until next milestone

First Submitted

Initial submission to the registry

March 6, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 17, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 21, 2023

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 28, 2024

Completed
Last Updated

September 3, 2025

Status Verified

September 1, 2025

Enrollment Period

10 months

First QC Date

March 6, 2023

Last Update Submit

September 2, 2025

Conditions

Keywords

physiotherapies techniquesRange of MotionHamstring MusclesPrevention and ControlMuscuoeskeletal Manipulations.

Outcome Measures

Primary Outcomes (1)

  • range of movements measurements

    Observe the degrees of mobility of the lower limb joints.

    1 month

Study Arms (3)

passive manual therapy

EXPERIMENTAL

The physiotherapist performs passive techniques on the hamstring muscles of the footballers.

Other: Passive Neurodynamics and Passive axial hip mobilisation/distraction

active therapy (exercise)

EXPERIMENTAL

The physiotherapist does not perform passive techniques and it is the player who performs active techniques on the hamstring muscles.

Other: Active therapy

combined therapy

ACTIVE COMPARATOR

The physiotherapist performs passive techniques and in addition the player performs active techniques on the hamstring muscles.

Other: 2.5.3. Combined therapy

Interventions

The physiotherapist performs passive techniques on the hamstring muscles and the nerve that innervates the hamstring muscles.

passive manual therapy

Active lumbopelvic CORE control exercises and active stretching of the ischiopelvic nerves

Also known as: Active Neurodynamics and Therapeutic exercise
active therapy (exercise)

The physiotherapist performs passive techniques on the hamstring muscles and the nerve that innervates the hamstring muscles and active lumbopelvic CORE control exercises and active stretching of the ischiopelvic nerves.

Also known as: Passive and Active therapy
combined therapy

Eligibility Criteria

Age18 Years - 40 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsFemale footballers
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Professional football athletes.
  • Between 18-40 years of age.
  • Female gender.
  • Active in competitive season.

You may not qualify if:

  • Neurological signs.
  • Inability to follow the evaluator's instructions.
  • Physical activity of less than 2 hours per week.
  • Serious lower limb injury during the study period.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universidad Católica de Ávila

Ávila, 05005, Spain

Location

Related Publications (8)

  • Petersen J, Holmich P. Evidence based prevention of hamstring injuries in sport. Br J Sports Med. 2005 Jun;39(6):319-23. doi: 10.1136/bjsm.2005.018549.

    PMID: 15911599BACKGROUND
  • Verrall GM, Slavotinek JP, Barnes PG. The effect of sports specific training on reducing the incidence of hamstring injuries in professional Australian Rules football players. Br J Sports Med. 2005 Jun;39(6):363-8. doi: 10.1136/bjsm.2005.018697.

    PMID: 15911608BACKGROUND
  • Hagglund M, Walden M, Ekstrand J. Injury recurrence is lower at the highest professional football level than at national and amateur levels: does sports medicine and sports physiotherapy deliver? Br J Sports Med. 2016 Jun;50(12):751-8. doi: 10.1136/bjsports-2015-095951. Epub 2016 Mar 25.

  • Ekstrand J, Hagglund M, Walden M. Epidemiology of muscle injuries in professional football (soccer). Am J Sports Med. 2011 Jun;39(6):1226-32. doi: 10.1177/0363546510395879. Epub 2011 Feb 18.

  • Hagglund M, Walden M, Ekstrand J. Risk factors for lower extremity muscle injury in professional soccer: the UEFA Injury Study. Am J Sports Med. 2013 Feb;41(2):327-35. doi: 10.1177/0363546512470634. Epub 2012 Dec 21.

  • Ekstrand J, Ueblacker P, Van Zoest W, Verheijen R, Vanhecke B, van Wijk M, Bengtsson H. Risk factors for hamstring muscle injury in male elite football: medical expert experience and conclusions from 15 European Champions League clubs. BMJ Open Sport Exerc Med. 2023 Jan 24;9(1):e001461. doi: 10.1136/bmjsem-2022-001461. eCollection 2023.

  • Woods C, Hawkins RD, Maltby S, Hulse M, Thomas A, Hodson A; Football Association Medical Research Programme. The Football Association Medical Research Programme: an audit of injuries in professional football--analysis of hamstring injuries. Br J Sports Med. 2004 Feb;38(1):36-41. doi: 10.1136/bjsm.2002.002352.

  • Arnason A, Andersen TE, Holme I, Engebretsen L, Bahr R. Prevention of hamstring strains in elite soccer: an intervention study. Scand J Med Sci Sports. 2008 Feb;18(1):40-8. doi: 10.1111/j.1600-0838.2006.00634.x. Epub 2007 Mar 12.

MeSH Terms

Interventions

Exercise Therapy

Intervention Hierarchy (Ancestors)

RehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy Modalities

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

March 6, 2023

First Posted

March 17, 2023

Study Start

March 1, 2023

Primary Completion

December 21, 2023

Study Completion

April 28, 2024

Last Updated

September 3, 2025

Record last verified: 2025-09

Locations