A Study of Cadonilimab Combined With Regorafenib in Patients With Advanced HCC

NCT05773105 | Unknown Phase 1

• 1 other identifier: B2023-002-01
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the efficacy and safety of cadonilimab combined with regorafenib in patients with HCC who progressed on systemic therapy.

Conditions

Advanced Hepatocellular Carcinoma

Keywords

bispecific antibody; advanced HCC; anti-PD-1 and CTLA-4

Outcome Measures

Primary Outcomes (1)

• Desease control rate (DCR)

  Defined as proportion of patients who have CR, PR or SD according to RECIST v1.1

  At the end of Cycle 2 (each cycle is 21 days)

Secondary Outcomes (4)

• Progression Free Survival (PFS)

  Up to two years

• Overall survival (OS)

  Up to two years

• Desease control rate (DCR)

  At the end of Cycle 2 (each cycle is 21 days)

• Adverse Events (AEs)

  Up to two years

Study Arms (1)

Cadonilimab+regorafenib

EXPERIMENTAL

Drug: Cadonilimab+regorafenib

Interventions

Cadonilimab+regorafenib DRUG

cadonilimab(10mg/kg, iv,Q3W,D1) + regorafenib(80mg,PO,QD,everyday)

Cadonilimab+regorafenib

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who have signed ICF and are able to perform follow-up visits and relevant procedures required in the protocol
• Age 18-75
• Histologically or pathologically confirmed hepatocellular carcinoma
• Barcelona Clinic Liver Cancer (BCLC) stage of B or C or CNLC IIb-IIIb, for those unsuitable for radical surgery and/or local treatment
• Previously treated with anti-vascular targeting combined with or without anti-PD-1/PD-L1 agents for HCC, with disease progression or intolerable toxicity
• Child-Pugh score of ≤ 7
• ECOG PS of 0 or 1
• At least 1 measurable lesion (according to RECIST1.1)
• Sufficient organ and bone marrow functions, with the laboratory test values within 7 days before the enrollment meeting the following requirements (no blood components, cell growth factors, albumin, and other drugs via intravenous or subcutaneous administrations are allowed for correction treatment within the first 14 days after the laboratory test results are obtained). The specific information is as follows:
• Routine blood test: absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L; platelet count (PLT) ≥ 50× 10\^9/L; hemoglobin (HGB) ≥ 9.0 g/dL.
• Hepatic function: total bilirubin (TBIL) ≤ 1.5 × upper limit of normal (ULN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN; serum albumin ≥ 28 g/L;
• Renal function: serum creatinine (Cr) ≤ 1.5 × ULN or clearance of creatinine (CCr)
• ≥ 60 mL/min (Cockcroft-Gault formula); urinalysis results showing urine protein \< 2+; patients whose baseline urinalysis results show urine protein ≥ 2+ should undergo 24-h urine collection and 24-h urine protein quantitation test result should be \< 1 g.
• Blood coagulation function: international normalized ratio (INR) and activated partial thromboplastin time (APTT) ≤ 1.5 × ULN.
• Estimated survival ≥ 12 weeks.

You may not qualify if:

• Histologically/cytologically confirmed fibrolamellar hepatocellular carcinoma, sarcomatoid hepatocellular carcinoma, and cholangiocarcinoma.
• History of hepatic encephalopathy or liver transplantation.
• Symptomatic pleural effusion, ascites, and pericardial effusion that require drainage.
• Acute or chronic active hepatitis B or C infection; hepatitis B virus (HBV) DNA \> 2000 IU/mL or 10\^4 copies/mL; hepatitis C virus (HCV) RNA \> 10\^3 copies/mL; hepatitis B surface antigen (HbsAg) and anti-HCV antibody positive concurrently. Those who possess the indicators lower than the above criteria after nucleotide antiviral treatment can be enrolled.
• Presence of metastasis to the central nervous system.
• Presence of bleeding events from esophageal or gastric varices caused by portal hypertension within the past 6 months. Presence of known severe (G3) varicose veins in endoscopy within 3 months before the first dose. Evidence of portal hypertension (including the finding of splenomegaly in imaging studies) with a high risk of bleeding assessed by the investigator
• Presence of any life-threatening bleeding events within the past 3 months, including the need for transfusion, surgery or local treatment, and continuous medication therapy.
• Any arterial/venous thromboembolic events within 6 months, including myocardial infarction, unstable angina, cerebrovascular accident or transient cerebral ischemic attack, pulmonary embolism, deep vein thrombosis, or any other history of serious thromboembolism. Presence of implantable venous port or catheter-derived thrombosis, or superficial venous thrombosis, barring stable thrombosis following the conventional anticoagulation treatment. Prophylactic use of low-dose low-molecular-weight heparin (e.g., enoxaparin 40 mg/day) is permitted.
• Involvement of both the main portal vein and the left and right branches by portal vein tumor thrombus, or of both the main trunk and the superior mesenteric vein concurrently. Presence of tumor thrombus of inferior vena cava.
• Uncontrolled hypertension (systolic greater than 140 mmHg or diastolic greater than 90 mmHg) after the optimal medical treatment, history of hypertensive crisis or hypertensive encephalopathy.
• Toxicity (excluding alopecia, events not clinically significant, and asymptomatic laboratory abnormalities) caused by previous therapy that has not yet resolved to grade 0 or 1 (National Cancer Institute Common Terminology Criteria for Adverse Events V5.0 (NCI CTCAE V5.0)) before the first dose of study drugs.
• Symptomatic congestive cardiac failure (NYHA Class II-IV).
• Serious hemorrhagic tendency or coagulopathy, or currently receiving thrombolytic therapy.
• History of gastrointestinal perforation and/or fistula, history of bowel obstruction (including incomplete bowel obstruction requiring parenteral nutrition), extensive bowel resection (partial colectomy or extensive small bowel resection accompanied with chronic diarrhea), Crohn's disease, ulcerative colitis, or chronic diarrhea within the past 6 months.
• History or current experience of pulmonary fibrosis and such lung diseases as interstitial pneumonia, pneumoconiosis, drug-related pneumonia, and severely impaired lung function.

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510060, China

Location

MeSH Terms

Conditions

Diabetes Mellitus, Insulin-Dependent, 12

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: March 6, 2023
• First Posted: March 17, 2023
• Study Start: February 28, 2023
• Primary Completion: February 1, 2024
• Study Completion: February 1, 2025
• Last Updated: January 16, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)