NCT05772117

Brief Summary

To evaluate the relative efficacy of an online intervention based on the Trans-theoretical Model delivered by a fully-automated Chatbot with natural language processing functions versus a control in promoting pneumococcal vaccination uptake among Hong Kong people aged ≥65 years. A total of 374 participants will be randomized evenly to either the intervention group or the control group. Participants in the intervention group will receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3. Participants in the control group will receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3. All participants will be followed up 6 and 12 months after completion of the intervention.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
374

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2023

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 6, 2023

Completed
7 days until next milestone

Study Start

First participant enrolled

March 13, 2023

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 16, 2023

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2024

Completed
Last Updated

April 6, 2023

Status Verified

April 1, 2023

Enrollment Period

1.5 years

First QC Date

March 6, 2023

Last Update Submit

April 4, 2023

Conditions

Vaccination Refusal

Outcome Measures

Primary Outcomes (1)

  • Pneumococcal vaccination uptake

    Self-reported uptake of pneumococcal vaccination within the 12-month follow-up period

    12 months

Study Arms (2)

Intervention

EXPERIMENTAL

Participants receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3.

Behavioral: Chatbot-delivered interventions tailored to stage of changes

Control

ACTIVE COMPARATOR

Participants receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3.

Behavioral: Chatbot-delivered standard interventions

Interventions

Chatbot-delivered interventions tailored to stage of changesBEHAVIORAL

Participants receive Chatbot-delivered interventions tailored to their stage of change regarding PV uptake in a conversational way at Month 0, 1, 2, and 3.

Intervention
Chatbot-delivered standard interventionsBEHAVIORAL

Participants receive Chatbot-delivered general information related to PV at Month 0, 1, 2, and 3.

Control

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • aged ≥65 years
  • having Hong Kong ID
  • Chinese speaking
  • have not received any penumococcal vaccination
  • willing to be followed up by telephone
  • having a smartphone
  • able to send and read text/voice messages via smartphone.

You may not qualify if:

  • blindness or deafness
  • not able to communicate with others effectively
  • with known contradictions of pneumococcal vaccination
  • having been diagnosed with major psychiatric illness
  • scored ≤16 in the validated telephone version of the Cantonese Mini-mental State Examination (T-CMMSE).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre for Health Behaviours Research, the Chinese University of Hong Kong

Hong Kong, 666888, Hong Kong

RECRUITING

Related Publications (1)

  • Wang Z, Chen S, Poon J, Han SC, Ye D, Yu FY, Fang Y, Ni Z, Wong MCS, Mo PKH. A Hybrid Chatbot to Promote Pneumococcal Vaccination Among Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2025 Oct 1;8(10):e2535813. doi: 10.1001/jamanetworkopen.2025.35813.

    PMID: 41060654DERIVED

MeSH Terms

Conditions

Vaccination Refusal

Condition Hierarchy (Ancestors)

Treatment RefusalTreatment Adherence and ComplianceHealth BehaviorBehavior

Central Study Contacts

Zixin Wang, PhD

CONTACT

+852 22528740wangzx@cuhk.edu.hk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

March 6, 2023

First Posted

March 16, 2023

Study Start

March 13, 2023

Primary Completion

August 31, 2024

Study Completion

August 31, 2024

Last Updated

April 6, 2023

Record last verified: 2023-04

Data Sharing

IPD Sharing
Will not share

Locations

HK(1)