Plasma Proteomics in Patients With Postoperative Delirium
Serum Biomarkers for Postoperative Delirium Based on Plasma Proteomic Analysis of Elder Patients Undergoing Cardiac Surgery
1 other identifier
observational
200
0 countries
N/A
Brief Summary
Patients undergoing cardiac surgery were recruited. Baseline characteristics of all subjects were collected. The 3-minute Delirium diagnostic Scale (3D-CAM) was used to screen the POD group and non-POD group from the recruited subjects during the first 7 days after surgery. Peripheral blood samples were collected 1 day before surgery and 2 day after surgery. . Plasma was isolated from peripheral blood for subsequent proteomic analysis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2023
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 18, 2023
CompletedFirst Posted
Study publicly available on registry
March 16, 2023
CompletedStudy Start
First participant enrolled
March 20, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2025
CompletedMarch 16, 2023
February 1, 2023
1.8 years
February 18, 2023
March 5, 2023
Conditions
Outcome Measures
Primary Outcomes (2)
Differences of Quantitative Proteomics between POD and non-POD
Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level.
1 day before surgery
Differences of Quantitative Proteomics between POD and non-POD after surgery
Plasma was isolated from peripheral blood for subsequent proteomic analysis. Investigators study the characteristics of proteins at a large-scale level.
2 day after surgery
Study Arms (2)
POD group
According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group
non-POD group
According to the occurrence of postoperative delirium, the patients were divided into POD group and non-POD group
Eligibility Criteria
Patients undergoing cardiac Surgery.
You may qualify if:
- Age ≥65 years old, regardless of gender.
- The patient had clear consciousness and no cognitive impairment, and could cooperate with the investigation and follow-up.
- The ASA classification is I-Ⅲ.
You may not qualify if:
- severe neurological or psychiatric disorders.
- drug and alcohol abuse.
- Patients with cognitive impairment caused by various reasons such as neuropsychiatric symptoms.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Yangzi Zhu, Doctor
Xuzhou Central Hospital
- PRINCIPAL INVESTIGATOR
Liwei Wang, Doctor
Xuzhou Central Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 18, 2023
First Posted
March 16, 2023
Study Start
March 20, 2023
Primary Completion
January 1, 2025
Study Completion
January 1, 2025
Last Updated
March 16, 2023
Record last verified: 2023-02
Data Sharing
- IPD Sharing
- Will not share