Effects of a Multi-Ingredient Pre-Workout Supplement on Body Composition, Performance, Muscular Properties, and Wellbeing in Adults.

NCT05769088 | Unknown

• 1 other identifier: UGreenwich3
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The investigation will be conducted as a double blinded, randomized, parallel between treatment conditions comparison design with two different groups ingesting a different supplement each one.

Conditions

Protein Deficiency; Training Group, Sensitivity; Fatigue; Muscular Atrophy; Psychological

Keywords

Fatigue; Supplement; Protein; Resistance Training; Pre-workout; Strength; Rate of Perceived Exertion; Muscle

Outcome Measures

Primary Outcomes (7)

• Tensiomyography

  A TMG portable device (TMG Measurement System, 146 TMG-BMC Ltd., Ljubljana, Slovenia) with a maximal stimulation output of 110 mA·ms-1 IS used to evaluate the contractile properties of the Anterior Deltoid (AD) of the dominant limb. Changes in the evoked muscular contractile properties are estimated by analysing maximal radial displacement of the muscle belly in millimetres (Dm).

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Vertical Jump

  Height (measured in centimetres)

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Chest Medicine Ball Throw

  Medicine Ball Throw (measured in meters and centimetres).

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Maximal Mid-Thigh Pull Isometric Strength

  Maximal Strength (measured in kilograms).

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Muscle Thickness

  Thickness of the Vastus Lateralis and the Elbow Flexors of the dominant limbs

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Self Perceived Energy Feeling

  All participants will fill a short questionnaire (from 1 to 5 points) about their perception of energy before every training. Energy Feeling will be assessed (Evergy level, Fatigue Level, Feeling of Alertness, and Feeling of Focus for the task, valued from 1 = low energy to 5 = high energy).

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

• Whole Body Perceptual Response during Resistance Training

  Self Rate of Perceived Exertion (RPE) will be assessed via OMNI RES Scale (0-10 values) during resistance training (after every circuit) and 15-20 minutes after finishing each session.

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

Secondary Outcomes (1)

• White Blood Cells count

  Changes from 3 days previous to, and 3 days after the completion of the 6-weeks training program

Study Arms (2)

Multi-Ingredient Pre-Workout Supplement

EXPERIMENTAL

A 60 g dose of a commercially available preworkout supplement providing 159 kcal including carbohydrates 15 g, essential amino acids 12 g, citrulline 3.5 g, Arginine, 3.5 g Taurine 1 g, L-Tyrosine 1 g, yerba mate 0.3 g and caffeine 0.4 g. With 350 ml of water.

Dietary Supplement: Ingestion of a Pre-Workout Supplement

Maltodextrin Supplement

PLACEBO COMPARATOR

A isoenergetic Maltodextrin supplement will be administered as placebo. With 350 ml of water.

Dietary Supplement: Ingestion of a Maltodextrin Supplement

Interventions

Ingestion of a Pre-Workout Supplement DIETARY_SUPPLEMENT

The Multi-Ingredient Pre-Workout Supplement is administered 15 minutes before the beginning of training sessions. No supplementation is administered in non-training days. The Resistance Training is performed in alternate days. The training Protocol is: 10 minutes of standardized warm-up, Strength Circuit training using free weights (Alternate Box Step-Ups, Bench Press; Parallel Squat; Up-right Row; Deadlift; Alternate Lunges; Shoulder Press; Leg Extension). The participants perform 16 repetitions of each exercise, with 30 seconds rest and 3 minutes rest after every set. If they can complete 16 repetitions easily, 2.5 to 5 kg are added for the next set. Also, whole-body Perceptual Response is assessed using the 0-10 OMNI-RES Scale, after every set and 15 minutes after finishing.

Multi-Ingredient Pre-Workout Supplement

Ingestion of a Maltodextrin Supplement DIETARY_SUPPLEMENT

The Maltodextrin Supplement is administered 15 minutes before the beginning of training sessions. No supplementation is administered in non-training days. The Resistance Training is performed in alternate days. The training Protocol is: 10 minutes of standardized warm-up, Strength Circuit training using free weights (Alternate Box Step-Ups, Bench Press; Parallel Squat; Up-right Row; Deadlift; Alternate Lunges; Shoulder Press; Leg Extension). The participants perform 16 repetitions of each exercise, with 30 seconds rest and 3 minutes rest after every set. If they can complete 16 repetitions easily, 2.5 to 5 kg are added for the next set. Also, whole-body Perceptual Response is assessed using the 0-10 OMNI-RES Scale, after every set and 15 minutes after finishing.

Maltodextrin Supplement

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy (no injuries, illnesses or medication intake).
• Between 45 and 65 years old.
• Active and familiarised with Resistance Training.

You may not qualify if:

• Unhealthy (illnesses or medication intake) or injured.
• Untrained.
• Young (\<45 y.o.) or elderly (\>65 y.o.).

Sponsors & Collaborators

• Joel Puente: lead
• Crown Sport Nutrition: collaborator
• Go Fit Spain: collaborator

Study Sites (1)

University of Greenwich, Avery Hill Campus, Sparrows Farm. Avery Hill, London., United Kingdom, SE9 2BT

London, Avery Hill, London., SE9 2BT, United Kingdom

Location

Related Publications (1)

• Puente-Fernandez J, Larumbe-Zabala E, Roberts J, Naclerio F. Effect of a Multi-Ingredient Post-Workout Dietary Supplement on Body Composition and Muscle Strength - A Randomized Controlled Trial. J Diet Suppl. 2025;22(3):445-462. doi: 10.1080/19390211.2025.2488811. Epub 2025 Apr 12.

  PMID: 40219860 DERIVED

MeSH Terms

Conditions

Protein Deficiency; Hypersensitivity; Fatigue; Muscular Atrophy

Condition Hierarchy (Ancestors)

Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Model Details: 6 Weeks of resistance training (alternate days), with a Pre-workout or Maltodextrin intake.

Study Record Dates

• First Submitted: February 20, 2023
• First Posted: March 15, 2023
• Study Start: March 15, 2023
• Primary Completion: May 15, 2023
• Study Completion: May 30, 2023
• Last Updated: March 15, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)