Trials Sponsors Conditions Drugs Pricing

Conditions

Acceleration Orthodontics Platelet-Rich Fibrin

Keywords

injectable platelets rich fibrin

Outcome Measures

Primary Outcomes (1)

Rate of canine retraction.
Rate of orthodontic tooth movement will be measured by calculating the difference in the canine position in mm throughout digital superimposition of consecutive digital models that will be made every four weeks.
5 months

Secondary Outcomes (1)

1. Assess bone level between intervention and control side.
bone level will be measured at the beginning of the study (T1) and by the fifth month of the study (T5)

Other Outcomes (1)

Assess Periodontal health at the injection side.
5 months

Study Arms (2)

injection site

EXPERIMENTAL

it is the arm where the patients will receive the PRF injection intraligamentally in distobuccal, and distopalatal areas of the distal surface of the canine also submucosal injection will be given buccally and palatially (0.25mm) for each side in either the right or left side of the arch.

Procedure: Injectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movement

control site

NO INTERVENTION

it is the arm where the patients will not receive any injection with the same method of retraction as the intervention side.

Interventions

Injectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movementProcedure

Preparatory phase * Space closure will be done on a 17x25 stainless steel wire * Both molars will be indirectly anchored to the miniscrew * Extend closing coil spring of suitable length from the canine hock to the first molar hock for retraction. * Apply a force of 150gm for each side. The force is measured by a force gauge and activated each visit to keep it constant all over the retraction phase. PRF Injection protocol * The First injection will be 3 weeks before extraction * By the end of the fourth week the patients will be referred for pre-intervention records. Upper arch CBCT will be obtained to take preintervention measurements of the alveolar bone. * At the time of canine retraction patient will receive another injection immediately and an alginate impression will be taken * follow up every month and injection will be repeated month after month with an observational period of 5 months.

Also known as: The effect of autologous platelet concentrates on orthodontic tooth movement

injection site

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age16 Years - 24 Years

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

adult patient
Full set of permanent dentition (excluding third molars).

Sponsors & Collaborators

Cairo University
Otherlead

Study Sites (1)

Vice president of graduate studies of Cairo University

Cairo, Giza Governorate, Egypt

RECRUITING

faculity of dentistry Cairo universityCONTACT+2023638755 ext. 530 ortho@dentistry.cu.edu.eg

Related Publications (31)

Aboalnaga AA, Salah Fayed MM, El-Ashmawi NA, Soliman SA. Effect of micro-osteoperforation on the rate of canine retraction: a split-mouth randomized controlled trial. Prog Orthod. 2019 Jun 3;20(1):21. doi: 10.1186/s40510-019-0274-0.
PMID: 31155698RESULT
Huang H, Williams RC, Kyrkanides S. Accelerated orthodontic tooth movement: molecular mechanisms. Am J Orthod Dentofacial Orthop. 2014 Nov;146(5):620-32. doi: 10.1016/j.ajodo.2014.07.007. Epub 2014 Oct 28.
PMID: 25439213RESULT

MeSH Terms

Interventions

proliferation regulatory factors, human urine

Study Officials

Mohamed M Alkhawaga, BDS
Cairo University
PRINCIPAL INVESTIGATOR
Fady Fahim, phD
Cairo University
STUDY DIRECTOR
Sally Magdy, phD
Cairo University
STUDY CHAIR

Central Study Contacts

Mohamed M Alkhawaga, BDS

CONTACT

+201099345694 mohamed.mamdouh@dentistry.cu.edu.eg

Study Design

Study Type: interventional
Phase: phase 3
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Doctor: Mohamed Mamdouh Mohamed Elmoghazy Alkhawaga

Study Record Dates

First Submitted

February 28, 2023

First Posted

March 13, 2023

Study Start

April 1, 2023

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

The Effect of Multiple Injections of (PRF) on The Rate of Canine Retraction

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Other Outcomes (1)

Study Arms (2)

injection site

control site

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (31)

MeSH Terms

Interventions

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Other Outcomes (1)

Study Arms (2)

injection site

control site

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (31)

MeSH Terms

Interventions

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations