The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults.

NCT05765422 | Recruiting

• 1 other identifier: 22-PP-11
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers predictive of future alterations. Current data show that the oral health of high level athletes is globally altered with an increase in cariogenic indexes, an increased incidence of periodontitis, dental trauma and dry mouth syndromes. Few studies have focused on the oral microbiota compared to mouthguards used in rugby or boxing which seem to induce dysbiosis, a recent study shows an effect of ketogenic diet on bacterial changes in the mouth of endurance athletes. This project focuses on the impact of intensive sport practice on oral health and the identification of oral biomarkers associated with physical activity. The objective of this study is to investigate the impact of the amount of endurance sport practice on oral microbiota and oral health in young adults. the hypothesis is that a sedentary lifestyle and high-level sport induce depletion and/or changes in the oral microbiota compared to regular physical activity.

Conditions

Microbial Colonization

Outcome Measures

Primary Outcomes (1)

• Analysis of the oral microbiota in healthy individuals engaged in endurance physical activity at different levels.

  Microbiological screening will be performed using an innovative methodology based on microfluidic PCR (BiomarkHD) (number of bacterial colonies)

  3 years

Secondary Outcomes (1)

• Quantification of salivary inflammatory markers in healthy individuals who perform endurance physical activity at different levels.

  3 years

Study Arms (3)

sedentary

OTHER

Participant does not meet WHO's recommendations with the physical activity

Other: salivar and gum sampling

OMS recommandations

OTHER

Participant does not meet WHO's recommendations (2.5-5 hours per week of moderate physical activity OR 1.25-2.5 hours per week of vigorous physical activity);

Other: salivar and gum sampling

More than the OMS recommandations

OTHER

Participant is practicing physical activity more than the WHO recommendations

Other: salivar and gum sampling

Interventions

salivar and gum sampling OTHER

Saliva will then be collected by salivary spit and a mucosal smear will be taken using a swab passed at the junction of the tooth and the gum

More than the OMS recommandations; OMS recommandations; sedentary

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be between 18 and 30 years old
• If practicing sports, it must be an endurance sport as main activity (cycling or running)

You may not qualify if:

• Practice more than 3 hours of swimming per week
• Have taken anti-inflammatory drugs, less than 48 hours before the study
• Have taken antibiotics and/or probiotics, less than 3 weeks before the study

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

Nice University Hospital

Nice, 06000, France

RECRUITING

Related Publications (1)

• Ortis M, Dubois M, Bougault V, Legueult K, Fassy J, Mari B, Bertrand MF, Lupi L, Doglio A. ORASPORT study protocol: a prospective observational study on the impact of endurance physical activity on oral microbiology and immunology. Front Oral Health. 2025 Dec 5;6:1692359. doi: 10.3389/froh.2025.1692359. eCollection 2025.

  PMID: 41424657 DERIVED

MeSH Terms

Conditions

Communicable Diseases

Condition Hierarchy (Ancestors)

Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Margaux DUBOIS, PH

CONTACT

0489152267; Margaux.DUBOIS@univ-cotedazur.fr

Morgane Ortis, PH

CONTACT

0489152267; Morgane.ORTIS@univ-cotedazur.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 1, 2023
• First Posted: March 13, 2023
• Study Start: October 17, 2022
• Primary Completion: March 15, 2026
• Study Completion: March 15, 2026
• Last Updated: May 17, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)