Screening for Lung Cancer in Subjects With Family History of Lung Cancer

NCT05762731 | Unknown

• 1 other identifier: HKU_UW_19_444
• Study Type: observational
• Target: 1,520
• Locations: 1 country
• Sites: 1

Brief Summary

Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.

Conditions

Lung Cancer

Keywords

Lung cancer; Screening; Family history

Outcome Measures

Primary Outcomes (1)

• The rate of lung cancer detection in subjects with family history of lung cancer

  The number of screening-detected lung cancer among first degree relatives of lung cancer patients.

  An average of 2.5 years

Secondary Outcomes (1)

• The characteristics of screening detected lung cancer

  An average of 2.5 years

Study Arms (2)

First degree relatives of lung cancer patients

Age 50-75, men or women, smokers or non-smokers. Being first degree relatives (siblings, children and parents) of lung cancer subjects. Having no known lung cancer before.

Diagnostic Test: Low dose CT thorax

Control group

Non-lung cancer subjects who are not related any lung cancer patients

Diagnostic Test: Low dose CT thorax

Interventions

Low dose CT thorax DIAGNOSTIC_TEST

A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.

First degree relatives of lung cancer patients

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects with lung cancer and to invite them to participate by (i) naming their first degree relatives to be further invited for the following study procedures, and (ii) provide a blood and urine sample as detailed below for archival and future analysis of relevant biomarkers. The patients' first degree relatives will be contacted by PA's research team and invited for study participation with the following study procedures.

You may qualify if:

• Age 50-75, men or women, smokers or non-smokers
• Being first degree relatives (Siblings, children, and parents) of lung cancer subjects
• Having no known lung cancer before

You may not qualify if:

• Non-Chinese
• Mentally incompetent to give informed consent

Sponsors & Collaborators

• The University of Hong Kong: lead
• The Queen Elizabeth Hospital: collaborator
• Kwong Wah Hospital: collaborator
• Hong Kong Sanatorium & Hospital: collaborator

Study Sites (1)

University of Hong Kong

Hong Kong, 0, Hong Kong

RECRUITING

Related Publications (20)

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Related Links

• Hong Kong Cancer Registry 2016 Hong Kong: Hospital Authority

Biospecimen

Retention: SAMPLES WITH DNA

Blood, urine samples

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 14, 2023
• First Posted: March 10, 2023
• Study Start: February 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2025
• Last Updated: March 10, 2023

Record last verified: 2023-01

Locations

HK (1)