Iris Color and Day-Night Changes in the Sympathovagal Ratio

NCT05759715 | Completed

• 1 other identifier: 1099/9.3.2016
• Study Type: observational
• Target: 621
• Locations: 0 countries
• Sites: N/A

Brief Summary

Iris melanocytes are innervated by parasympathetic and sympathetic nerve endings. Light affects autonomic nervous system activity via the retino-hypothalamic pathway. The hypothesis that the day-to-night variations in the sympatovagal ratio (LF/HF) may differ among individuals with different brown iris patterns was tested.

Conditions

Iris Diseases

Keywords

LF/HF ratio, iris color, melanin

Outcome Measures

Primary Outcomes (1)

• LF/HF ratio

  low frequency (LF, 0.04-0.15 Hz) and high frequency (HF, 0.16-0.4 Hz) measurements were taken from day and night changes in the heart rate by using the frequency-domain analysis method.

  one week

Study Arms (6)

2-0 darkbown-green (2-0 bg)

Those with distinctively dark brown in the central area, slightly green in the peripheral area,

Other: Iris Color Measurement , LF/HF Measurement

1-0 lightbrown-green (1-0 bg).

Those with slightly dark brown in the central area and green in the peripheral area,

Other: Iris Color Measurement , LF/HF Measurement

dark brown (1-1 db)

Eyes with the same color structure in the central iris and the peripheral iris.

Other: Iris Color Measurement , LF/HF Measurement

light brown (1-1 lb)

Eyes with the same color structure in the central iris and the peripheral iris.

Other: Iris Color Measurement , LF/HF Measurement

dark brown (2-0 b)

Those with distinctively dark brown in the central iris area compared to the periphery .

Other: Iris Color Measurement , LF/HF Measurement

slightly dark brown (1-0 b)

Those with slightly dark brown (1-0 b) in the central iris area compared to the periphery .

Other: Iris Color Measurement , LF/HF Measurement

Interventions

Iris Color Measurement , LF/HF Measurement OTHER

Iris Color Measurement (Photos were taken of the iris with a digital camera ) LF/ HF Measurement (Using the three-channel standard ambulatory Holter recording system)

1-0 lightbrown-green (1-0 bg).; 2-0 darkbown-green (2-0 bg); dark brown (1-1 db); dark brown (2-0 b); light brown (1-1 lb); slightly dark brown (1-0 b)

Eligibility Criteria

• Age: 16 Years - 50 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

A total of 650 healthy individuals between the ages of 16 and 50 who applied for cardiac examination and had normal findings were recruited for the study.

You may qualify if:

• A total of 650 healthy individuals between the ages of 16 and 50 .

You may not qualify if:

• Diseases that could affect the autonomic nervous system; Obesity Obstructive sleep apnea syndrome Hypertension Diabetes mellitus Atrial fibrillation Coronary disease Heart failure Goiter, etc.

Sponsors & Collaborators

• Ankara Ataturk Sanatorium Training and Research Hospital: lead

MeSH Terms

Conditions

Iris Diseases

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD Cardıologist

Study Record Dates

• First Submitted: February 27, 2023
• First Posted: March 8, 2023
• Study Start: May 5, 2016
• Primary Completion: May 5, 2022
• Study Completion: June 1, 2022
• Last Updated: March 9, 2023

Record last verified: 2023-03