NCT05756036

Brief Summary

To seek an association between Torque Teno Virus DNA titres resulting from under or over-immunosuppression in a kidney allograft recipient, Graft rejection, both cell-mediated rejection and antibody-mediated rejection, donor-specific antibodies (DSA), the incidence of BK viraemia and BK nephropathy, CMV infection or diseases and PCP infection and the number of circulating NK, B and T lymphocyte subtypes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
268

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2022

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 15, 2022

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

February 23, 2023

Completed
11 days until next milestone

First Posted

Study publicly available on registry

March 6, 2023

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2025

Completed
Last Updated

February 23, 2026

Status Verified

February 1, 2026

Enrollment Period

3.5 years

First QC Date

February 23, 2023

Last Update Submit

February 19, 2026

Conditions

Renal Transplant RejectionImmunosuppressionRenal Transplant FailureRenal Transplant Infection

Keywords

renal transplantimmunosuppressionTorque teno virus

Outcome Measures

Primary Outcomes (1)

  • The correlation between TTV viral load and Biopsy proven graft rejection

    6 months

Study Arms (1)

Renal transplant recipients

All incident renal transplant recipients after the commencement of the study

Other: None Observational study

Interventions

None Observational studyOTHER

Non interventional study

Renal transplant recipients

Eligibility Criteria

Age16 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All consenting renal transplant recipients in the study period

You may qualify if:

  • All consenting renal transplant recipients in the study period will be included in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Royal London Hospital

London, SW4 8FA, United Kingdom

Location

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 23, 2023

First Posted

March 6, 2023

Study Start

February 15, 2022

Primary Completion

August 31, 2025

Study Completion

August 31, 2025

Last Updated

February 23, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)