Survey About the Relationship Beetween Allergic Rhinitis and Seasonal EOE Exacerbations

NCT05755477 | Unknown

• 1 other identifier: 3638
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Eosinophilic esophagitis (EoE) is a chronic inflammatory esophagus disease that is presented in patients with a history of recurrent dysphagia. EoE is closely related to other pathologies with an immuno-allergic etiopathogenesis such as atopic dermatitis (AD), IgE-mediated food allergy, allergic rhinitis and bronchial asthma. While the importance of the correlation between diet and food allergy has been largely demonstrated, less is known about the exact role of sensitization to aerollergens in the progression and recrudescence of symptoms. In support of this correlation there is evidence of a seasonal trend in the new diagnoses of EoE, of the possibility of the de-novo onset of the pathology following massive exposure to a specific aeroallergen and the demonstration that the degree of esophageal eosinophilia varies according to the climatic zone and the season of the year. The detailed knowledge of this correlation could clarify some aspects of the etiopathogenesis and natural history of EoE, improve and personalize the clinical-diagnostic management of affected patients and provide new therapeutic targets. Our aim is evaluating the possible existence of a correlation between the recrudescence of dysphagia symptoms and a specific month of the year and/or specific season.

Conditions

Eosinophilic Esophagitis; Respiratory Allergy

Outcome Measures

Primary Outcomes (1)

• Correlation between the recrudescence of dysphagia symptoms and Seasons

  Evaluate the possible correlation between the recrudescence of dysphagia symptoms and a specific month of the year and/or specific season.

  12 months

Secondary Outcomes (2)

• Correlation between the anamnestic onset of the disease and the individual patient's sensitization to aeroallergens.

  12 months

• Prevalence of respiratory allergy (rhinitis and allergic asthma) in patients with EoE.

  12 months

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All the subjects (both sex) between 18 and 75 years old with EOE diagnosis

You may qualify if:

• All the subjects with EOE diagnosis

You may not qualify if:

• All the patients without EOE diagnosis

Sponsors & Collaborators

• Nucera Eleonora: lead

Study Sites (1)

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168, Italy

RECRUITING

MeSH Terms

Conditions

Eosinophilic Esophagitis

Condition Hierarchy (Ancestors)

Esophagitis; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Gastroenteritis; Eosinophilia; Leukocyte Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Central Study Contacts

Eleonora NUCERA, PROF.

CONTACT

390630154965; eleonora.nucera@policlinicogemelli.it

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor, MD

Study Record Dates

• First Submitted: February 21, 2023
• First Posted: March 6, 2023
• Study Start: January 3, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: March 6, 2023

Record last verified: 2023-03

Locations

IT (1)