A Multidimensional Study on Articulation Deficits in Parkinsons Disease

NCT05754086 | Completed

• 2 other identifiers: STUDY00002525F31DC020121
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Articulatory deficits are present in most speakers with dysarthria, which negatively impacts their speech intelligibility, yet little is known about the relationship between articulatory movement and speech intelligibility. This study will examine the relationship between articulation measures, both acoustic and kinematic, and their relationship to perceptual measures (i.e., speech intelligibility and articulation ratings) in 30 individuals with dysarthria secondary to Parkinson's disease and 30 neurologically healthy adults of the same age. The findings will have implications for behavioral management.

Conditions

Parkinson Disease; Dysarthria, Hypokinetic

Outcome Measures

Primary Outcomes (5)

• Vowel Space Area

  Vowel space area is a measure of the planar area among the four corner vowels /i/, /ae/, /a/, and /u/. It is calculated using the first and second formant resonant frequencies obtained from the acoustic signal, using the software PRAAT.

  Baseline

• F2 Slope

  Second formant frequency (F2) slope is measured as the rate of F2 change during the diphthong in "Buy." To calculate this measure, first the investigators will obtain the extent of F2 change (max F2 - min F2) from the diphthong "Buy." Then this F2 change is divided by the duration of the diphthong "Buy."

  Baseline

• Tongue and Jaw Speed

  This is measured as the tongue and jaw speed during the diphthong in "Buy". Specifically, this will be calculated as tongue/jaw movement (measured in mm), divided by movement duration (measured in ms). The tongue and jaw movement will be collected using the electromagnetic articulography (EMA) device used in this study.

  Baseline

• Acoustic Distance

  This is measured as the Euclidean distance between the second formant frequency (F2) onset and offset of the diphthong in "Buy" in an F1-F2 (first and second formant frequency) space. Measured in Hz.

  Baseline

• Tongue and Jaw Distance

  This is measured as the Euclidean distance between the tongue and jaw onset and offset of the diphthong in "Buy" in a two-dimensional space.The tongue and jaw movement will be collected using the electromagnetic articulography (EMA) device used in this study.

  Baseline

Study Arms (2)

Parkinsons (PD) Group

This cohort includes individuals who have been diagnosed with Parkinson's disease.

Behavioral: Clear Speech; Behavioral: Less Clear Speech

Neurotypical (NT) Group

This group consists of age-matched control participants. They are neurologically healthy and do not have any neurological diagnoses.

Behavioral: Clear Speech; Behavioral: Less Clear Speech

Interventions

Clear Speech BEHAVIORAL

This behavioral modification asks participants to speak more clearly, as if they were "speaking to someone with a hearing loss".

Neurotypical (NT) Group; Parkinsons (PD) Group

Less Clear Speech BEHAVIORAL

This behavioral modification asks participants to speak less clearly, as if they were "in a room with many people and they were mumbling something to the person next to them that they didn't want other people in the room to hear."

Neurotypical (NT) Group; Parkinsons (PD) Group

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All participants will be recruited via convenient sampling from Tallahassee, FL, and the local community. For the neurologically healthy control speakers, flyers will be posted at local coffee shops, community samples, and via word of mouth. For the Parkinson's participants, flyers will be posted at hospitals, health clinics, and gyms.

You may qualify if:

• neurological diagnosis of PD (for the PD group only)
• diagnosis of dysarthria (for the PD group only)
• native English speaker
• no evidence of cognitive impairment, as indicated by a score above 26 on the Montreal Cognitive Assessment
• able to read a paragraph in 19-point font

You may not qualify if:

• Not within the age limits

Sponsors & Collaborators

• Florida State University: lead
• National Institute on Deafness and Other Communication Disorders (NIDCD): collaborator

Study Sites (1)

Florida State University

Tallahassee, Florida, 32309, United States

Location

MeSH Terms

Conditions

Parkinson Disease; Dysarthria

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Articulation Disorders; Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Yunjung Kim, Ph.D.

  Florida State University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 22, 2023
• First Posted: March 3, 2023
• Study Start: September 9, 2021
• Primary Completion: July 31, 2023
• Study Completion: July 31, 2023
• Last Updated: August 27, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: Analytic data and code will be made available in July 2023.
• Access Criteria: Upon publication to the open science framework (OSF) project page, anyone will have access to the analytic data and code.

Locations

US (1)