Association Between PM2.5 and Ferroptosis

NCT05753332 | Unknown

• 1 other identifier: NorthernJiangsu-zhao
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This cohort study aims to discover the possible effects of PM2.5 exposures on the Nrf2- dependent ferroptosis pathway. This observational cohort's main question is whether PM2.5 exposures will affect the Nrf2- dependent ferroptosis pathway. Participants will be divided into two groups: the control group and the air pollution to detect the biomarkers of the Nrf2- dependent ferroptosis pathway.

Conditions

Exposure to Polluted Air

Keywords

PM2.5; Nrf2; Cognitive function; Ferroptosis

Outcome Measures

Primary Outcomes (3)

• 4HNE level

  Biomarkers of ferroptosis, an indicator of lipid reactive oxygen species

  From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 120 days

• TNF-α ELISA KIT

  Biomarkers of the proinflammatory cytokines

  From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 120 days

• mRNA expression of the Nrf2- dependent ferroptosis

  Biomarkers of the Nrf2- dependent ferroptosis

  From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 120 days

Study Arms (2)

The control group

the invited volunteers live in Yangzhou, Jiangsu, China (low PM2.5 level based on previous official PM2.5 records)

The PM2.5 exposure group

the invited volunteers live in Xuzhou, Jiangsu, China (high PM2.5 level based on previous official PM2.5 records)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The control group will be selected from the invited volunteers who live in Yangzhou city via the website, email, and poster. The PM2.5 group will be selected from the invited volunteers who live in Xuzhou city via the website, email, and poster.

You may qualify if:

• Aged over 18 years old living in this city for more than one year no exposure to any chemistry pollution before

You may not qualify if:

• Aged below 18 years old neurological disorders; endocrine diseases; cancer significant changes in biomarkers (TNF-α, Nrf2, SLC7A11, GPX4) at the beginning

Sponsors & Collaborators

• Northern Jiangsu People's Hospital: lead
• Xuzhou Medical University: collaborator

Study Sites (1)

Wenjing Zhao

Yangzhou, Jiangsu, 225001, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

the enrolled participant's peripheral whole blood samples

Study Officials

• Ju Gao, Phd

  Affiliated Northern Jiangsu People's Hospital of Yangzhou University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.; attending doctor

Study Record Dates

• First Submitted: February 6, 2023
• First Posted: March 3, 2023
• Study Start: December 1, 2022
• Primary Completion: February 25, 2023
• Study Completion: March 1, 2023
• Last Updated: March 3, 2023

Record last verified: 2023-02

Locations

CN (1)