Procedural Motor Memory in Long COVID-19

NCT05746624 | Completed

• 2 other identifiers: 10000466000466-N
• Study Type: observational
• Target: 333
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Most people who get COVID-19 seem to recover with no long-term effects. However, some people who recover from acute COVID-19 infections report lingering symptoms. This is called long COVID. Many people with long COVID report symptoms related to the nervous system; these can include problems with fatigue, speech, and memory. Objective: To test motor memory in people with long COVID, compared to healthy volunteers. Eligibility: People aged 18 to 90 years who are also enrolled in study protocol 000089. Healthy adults are also needed. Design: Participants will be screened by telephone. They will confirm they are able to type without discomfort using their nondominant hand. They will confirm they have access to a computer connected to the internet. All study tasks will be done online. Participants will complete 2 tasks in 2 days. Participants will be sent a link to a website. The website will give them instructions. They will place the fingers of their nondominant hand over 4 numbers on the keyboard and type a sequence (eg, 4-1-3-2-4). They will type this sequence as often as they can in 10 seconds. Then they will rest for 10 seconds before repeating the task. They will repeat this pattern for 15 minutes. After they finish the typing task, participants will take a 10-minute questionnaire. They will answer questions about their experiences with COVID-19 and memory issues; they will say which hand they use for tasks such as brushing their teeth or throwing a ball. Participants will get a notice to repeat the typing task 22 hours after they finish the first one. They should complete the second task within 28 hours....

Conditions

Infectious Metabolic Encephalopathy; Ischemic Stroke; Seizure; Viral Encephalitis, Small and Large Vessel

Keywords

Corona Virus

Outcome Measures

Primary Outcomes (1)

• To investigate differences in procedural memory formation and consolidation during a keyboard typing task between o patients withpersistent symptoms following COVID- 19 infection ( long COVID )and matched controls who deny symptoms of ...

  Early procedural motor memory learning will be measuredby the difference in keypress speed between the first training trial and last correct training trial of the Day 1 typing task.

  anticipated to complete data analysis by December 2023

Study Arms (4)

Arm 1 Long COVID left handed

Long COVID left handed

Behavioral: keypresses

Arm 1 Long COVID right handed

Long COVID right handed

Behavioral: keypresses

Arm 2 Healthy Controls left handed

healthy left handed

Behavioral: keypresses

Arm 2 Healthy Controls right handed

healthy right handed

Behavioral: keypresses

Interventions

keypresses BEHAVIORAL

benign behavioral intervention-- keypresses

Arm 1 Long COVID left handed; Arm 1 Long COVID right handed; Arm 2 Healthy Controls left handed; Arm 2 Healthy Controls right handed

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with long COVID were recruited from NIH protocol 000089 Post- Coronavirus Disease 19 Convalescence at the National Institutes of Health . These subjects were matched by age and sex to healthy volunteers recruited online using the Prolific.co crowdsourcing platform. All participants were able to review and understand acknowledgment of participation, age 18 at time of enrollment, English-speaking, able to type without discomfort, and with access to a physical keyboard. Healthy volunteers additionally reported not having active fever or residual symptoms following Covid infection.

You may qualify if:

• In order to be eligible to participate in this study, patient volunteers must meet all of the following criteria:
• Ability of subject to understand and the willingness to review an informed consent
• Aged at least 18 years at the time of enrollment, and no older than 90 years of age.
• Identity of dominant hand
• Question: Which hand would you choose to hold the pen to write a formal letter?
• English-Speaking:
• Ability to type without discomfort using non-dominant hand
• Enrolled in the screening phase of Protocol 000089 Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health in the post-COVID convalescence arm (i.e. reports having started recovery from an acute COVID- 19 infection within past six month and is able to provide documentation of a positive COVID-19 PCR or antibody test)
• In order to be eligible to participate in this study, healthy volunteers must meet all of the following criteria:
• Ability of subject to understand and the willingness to review an acknowledgement of participation agreement
• Aged at least 18 years at the time of enrollment, and no older than 90 years of age
• English-speaking
• Ability to identify dominant hand
• Question: Which hand would you choose to hold the pen to write a formal letter?
• Ability to type without discomfort using non-dominant hand

You may not qualify if:

• Patient group: A patient who meets any of the following criteria will be excluded from participation in this study:
• A condition prior to the diagnosis of COVID-19 infection that would significantly confound interpretation of the behavioral task, as determined by the screening clinician (e.g., prior diagnosis of a neurologic condition such as large stroke, Alzheimer s disease or Parkinson s disease, or severe psychiatric condition).
• Staff from our section, and their immediate family members
• Healthy Volunteer group: A person who meets any of the following criteria will be excluded from participation in this study:
• A condition that would significantly confound interpretation of the research tests as determined by the screening clinician (e.g., prior diagnosis of a neurologic condition such as large stroke, Alzheimer s disease or Parkinson s disease, or severe psychiatric condition)
• Fever, respiratory symptoms or diagnosis of COVID-19 in the last 14 days.
• History of COVID-19 with residual neurologic symptoms following diagnosis that did not resolve within 14 days of disease onset.
• Previous participation in this study (platform filter).

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institute of Neurological Disorders and Stroke (NINDS)

Bethesda, Maryland, 20892, United States

Location

MeSH Terms

Conditions

Ischemic Stroke; Seizures; Encephalitis, Viral; Cerebral Palsy

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Central Nervous System Viral Diseases; Central Nervous System Infections; Infections; Infectious Encephalitis; Virus Diseases; Encephalitis; Neuroinflammatory Diseases; Brain Damage, Chronic

Study Officials

• Leonardo G Cohen, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 18, 2023
• First Posted: February 28, 2023
• Study Start: November 15, 2021
• Primary Completion: March 17, 2022
• Study Completion: March 17, 2022
• Last Updated: March 30, 2025

Record last verified: 2025-03-27

Locations

US (1)