Chongqing Adrenogenic Autonomic Cortisol Secretion Cohort Study

NCT05743933 | Recruiting DMC

• 1 other identifier: AC-China 2023
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

To investige the etiology, pathogenesis, diagnosis and treatment of adrenogenic autonomic cortisol secretion in Chinese adults.

Conditions

Diagnosis; Treatment; Adrenogenic Autonomic Cortisol Secretion

Keywords

Diagnosis and differential diagnosis; Treatment and prognosis; Adrenogenic Autonomic Cortisol Secretion

Outcome Measures

Primary Outcomes (1)

• SUVmax value of PET-CT

  To explore the value of 68\[Ga\]-Pentixafor PET-CT in the diagnosis of MACS

  10 years

Secondary Outcomes (1)

• Etiology and pathogenesis of adrenogenic autonomic cortisol secretion

  10 years

Study Arms (2)

Study group

Accidental adrenal tumor with 1mg-DST cortisol \>50nmol/L

Control group

Accidental adrenal tumor with 1mg-DST cortisol ≤50nmol/L

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People with adrenal incidentaloma and serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test, without other situation mentioned in exclusion criteria.

You may qualify if:

• CT examination revealed adrenal nodules (maximum diameter ≥10mm);
• Serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST).

You may not qualify if:

• Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function.
• Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy.
• Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis.
• Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.

Sponsors & Collaborators

• Chongqing Medical University: lead

Study Sites (1)

Department of Endocrinology, Sichuan-Chongqing Joint Key Laboratory of Metabolic Vascular Diseases, Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

RECRUITING

Related Publications (3)

• Jing Y, Hu J, Luo R, Mao Y, Luo Z, Zhang M, Yang J, Song Y, Feng Z, Wang Z, Cheng Q, Ma L, Yang Y, Zhong L, Du Z, Wang Y, Luo T, He W, Sun Y, Lv F, Li Q, Yang S. Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study. Ann Intern Med. 2022 Oct;175(10):1383-1391. doi: 10.7326/M22-1619. Epub 2022 Sep 13.

  PMID: 36095315 RESULT

• Prete A, Subramanian A, Bancos I, Chortis V, Tsagarakis S, Lang K, Macech M, Delivanis DA, Pupovac ID, Reimondo G, Marina LV, Deutschbein T, Balomenaki M, O'Reilly MW, Gilligan LC, Jenkinson C, Bednarczuk T, Zhang CD, Dusek T, Diamantopoulos A, Asia M, Kondracka A, Li D, Masjkur JR, Quinkler M, Ueland GA, Dennedy MC, Beuschlein F, Tabarin A, Fassnacht M, Ivovic M, Terzolo M, Kastelan D, Young WF Jr, Manolopoulos KN, Ambroziak U, Vassiliadi DA, Taylor AE, Sitch AJ, Nirantharakumar K, Arlt W; ENSAT EURINE-ACT Investigators*; ENSAT EURINE-ACT Investigators. Cardiometabolic Disease Burden and Steroid Excretion in Benign Adrenal Tumors : A Cross-Sectional Multicenter Study. Ann Intern Med. 2022 Mar;175(3):325-334. doi: 10.7326/M21-1737. Epub 2022 Jan 4.

  PMID: 34978855 RESULT

• Deutschbein T, Reimondo G, Di Dalmazi G, Bancos I, Patrova J, Vassiliadi DA, Nekic AB, Debono M, Lardo P, Ceccato F, Petramala L, Prete A, Chiodini I, Ivovic M, Pazaitou-Panayiotou K, Alexandraki KI, Hanzu FA, Loli P, Yener S, Langton K, Spyroglou A, Kocjan T, Zacharieva S, Valdes N, Ambroziak U, Suzuki M, Detomas M, Puglisi S, Tucci L, Delivanis DA, Margaritopoulos D, Dusek T, Maggio R, Scaroni C, Concistre A, Ronchi CL, Altieri B, Mosconi C, Diamantopoulos A, Iniguez-Ariza NM, Vicennati V, Pia A, Kroiss M, Kaltsas G, Chrisoulidou A, Marina LV, Morelli V, Arlt W, Letizia C, Boscaro M, Stigliano A, Kastelan D, Tsagarakis S, Athimulam S, Pagotto U, Maeder U, Falhammar H, Newell-Price J, Terzolo M, Fassnacht M. Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study. Lancet Diabetes Endocrinol. 2022 Jul;10(7):499-508. doi: 10.1016/S2213-8587(22)00100-0. Epub 2022 May 6.

  PMID: 35533704 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Some subtye of disease should be diagnosed by DNA

MeSH Terms

Conditions

Disease

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Qifu Li, PhD

  First Affiliated Hospital of Chongqing Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Qifu Li, PhD

CONTACT

+86-023-89011552; liqifu@yeah.net

Shumin Yang, PhD

CONTACT

+86-023-89011552; 443068494@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: February 16, 2023
• First Posted: February 24, 2023
• Study Start: February 17, 2023
• Primary Completion (Estimated): February 15, 2033
• Study Completion (Estimated): February 15, 2033
• Last Updated: September 24, 2026

Record last verified: 2025-11

Locations

CN (1)