NCT05741723

Brief Summary

The objective of this post-approval study is to evaluate long-term outcomes of patients enrolled in the OCS DCD Heart and OCS DCD Heart CAP studies.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
276

participants targeted

Target at P75+ for all trials

Timeline
5mo left

Started Nov 2019

Longer than P75 for all trials

Geographic Reach
1 country

20 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress94%
Nov 2019Oct 2026

Study Start

First participant enrolled

November 26, 2019

Completed
3.2 years until next milestone

First Submitted

Initial submission to the registry

February 13, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

February 23, 2023

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2026

Last Updated

September 9, 2025

Status Verified

September 1, 2025

Enrollment Period

6.9 years

First QC Date

February 13, 2023

Last Update Submit

September 2, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Patient survival

    Patient survival through 5 years post-transplant

    5 years post-transplant

Other Outcomes (3)

  • Cardiac related patient survival

    5 years post-transplant

  • Graft survival

    5 years post-transplant

  • Patient and graft survival

    5 years post-transplant

Interventions

OCS HeartDEVICE

Transplanted with OCS preserved heart.

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients transplanted in the OCS DCD Heart Trial and OCS DCD Heart CAP will comprise the patient population for this PAS.

You may qualify if:

  • Patients transplanted in the OCS DCD Heart Trial and OCS DCD Heart CAP trials.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (20)

University of California San Diago

La Jolla, California, 92037, United States

Location

Stanford University

Palo Alto, California, 94304, United States

Location

Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

Location

Mayo Clinic Florida

Jacksonville, Florida, 32224, United States

Location

AdventHealth Orlando

Orlando, Florida, 32803, United States

Location

Emory University Hospital

Atlanta, Georgia, 30322, United States

Location

Northwestern Medicine

Chicago, Illinois, 60611, United States

Location

St. Vincent Cardiovascular Research Institute

Indianapolis, Indiana, 46260, United States

Location

Tufts Medical Center

Boston, Massachusetts, 02111, United States

Location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Minneapolis Heart Institute

Minneapolis, Minnesota, 55407, United States

Location

University of Minnesota

Minneapolis, Minnesota, 55414, United States

Location

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

Location

Nyph/Cumc

New York, New York, 10032, United States

Location

Montefiore

The Bronx, New York, 10467, United States

Location

Duke University

Durham, North Carolina, 27710, United States

Location

Vanderbilt Medical Center

Nashville, Tennessee, 37232, United States

Location

Sentara

Norfolk, Virginia, 23502, United States

Location

University of Wisconsin

Madison, Wisconsin, 53792, United States

Location

Froedtert & the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

Location

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Target Duration
5 Years
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 13, 2023

First Posted

February 23, 2023

Study Start

November 26, 2019

Primary Completion (Estimated)

October 1, 2026

Study Completion (Estimated)

October 1, 2026

Last Updated

September 9, 2025

Record last verified: 2025-09

Locations