NCT05741112

Brief Summary

To further characterize Long COVID-19 by collecting data from individuals who already own wearable devices or are provided with a wearable device along with basic and enhanced educational materials to determine if both can improve Long COVID-19 symptom management and post-exertional malaise.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100,500

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2023

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 23, 2023

Completed
9 months until next milestone

Study Start

First participant enrolled

November 16, 2023

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2025

Completed
Last Updated

May 11, 2025

Status Verified

May 1, 2025

Enrollment Period

2 years

First QC Date

February 17, 2023

Last Update Submit

May 9, 2025

Conditions

Outcome Measures

Primary Outcomes (2)

  • Primary Objective 1:Assess the effect of study-provided devices and enhanced educational materials to manage Long COVID-19 symptom severity, compared to general educational materials alone using data from participants survey responses.

    Will measure relapse symptom frequency, symptom severity, pain, quality of life and overall health through the analysis and measurement of change in the weekly survey responses.

    3 months

  • Primary Objective 2: Collate a unique longitudinal dataset combining patients' demographics, symptoms, symptom severity, quality of life, and sensor data including sleep, activity, heart rate, heart rate variability, and Body Battery.

    Will measure relapse symptom frequency, symptom severity, pain, quality of life and overall health through the analysis and measurement of change from the baseline survey to the quarterly survey.

    12 months

Secondary Outcomes (1)

  • Secondary Objective: Assess the longitudinal impact of sustained use of the study-provided devices and enhanced educational materials on symptom severity.

    12 months

Other Outcomes (1)

  • Exploratory Objective: Assess whether individuals who enroll in the study with their own wrist-worn wearable device and receive educational materials see a decrease in symptom severity and whether this differs by device brand and/or feature.

    12 months

Study Arms (4)

Control: study provided wearables

OTHER

Following consent and the completion of the baseline assessments the control group will receive basic education on symptom management. At the 3 month timepoint they will be prompted to order their device and receive enhanced education that will provide information on how wearable devices can be used to monitor and manage symptoms.

Device: Wearable device

Treatment: study provided wearables

OTHER

Following consent and the completion of the baseline assessments the treatment group will be prompted to order their device and receive basic education on symptom management along with the enhanced education on wearable devices.

Device: Wearable device

Control: self provided wearables

OTHER

Following consent and the completion of the baseline assessments the control group will receive basic education on symptom management. At the 3 month timepoint they will be receive enhanced education that will provide information on how wearable devices can be used to monitor and manage symptoms.

Device: Wearable device

Treatment: self provided wearables

OTHER

Following consent and the completion of the baseline assessments the treatment group will receive basic education on symptom management along with the enhanced education on wearable devices.

Device: Wearable device

Interventions

The treatment group will receive their wearable device and the enhanced education at the start of the study. Their outcomes will be compared with the control group who will receive at 3 months.

Also known as: Educational materials
Control: self provided wearablesControl: study provided wearablesTreatment: self provided wearablesTreatment: study provided wearables

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Is at least 18 years old.
  • Has a self/and or physician diagnosis of:
  • Long COVID (based on the WHO working definition),
  • ME/CFS (myalgic encephalomyelitis / chronic fatigue syndrome, self-diagnosis based on IOM criteria), and/or
  • POTS (Postural Orthostatic Tachycardia Syndrome).
  • Is interested in tools to manage ME/CFS, POTS, and/or Long COVID symptoms.
  • Owns a wearable device they are willing to use for this study or does not own a device and agrees to utilize a study-provided one.
  • Agrees to wear the device throughout the study period, share the data with the study, and sync data at least weekly.
  • Has access to a smartphone or tablet to enable syncing wearable data and viewing device feedback.
  • Agrees to disclose involvement in other ME/CFS, POTS, and/or Long COVID interventions such as medical treatment, self-management, and other interventional studies.
  • Agrees to complete at least 75% of the study surveys.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Scripps Research

La Jolla, California, 92037, United States

RECRUITING

MeSH Terms

Conditions

Post-Acute COVID-19 SyndromePostural Orthostatic Tachycardia SyndromeAutonomic Nervous System DiseasesFatigue Syndrome, Chronic

Interventions

Wearable Electronic Devices

Condition Hierarchy (Ancestors)

COVID-19Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract DiseasesPost-Infectious DisordersChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsOrthostatic IntolerancePrimary DysautonomiasNervous System DiseasesMuscular DiseasesMusculoskeletal DiseasesEncephalomyelitisNeuroinflammatory DiseasesNeuromuscular Diseases

Intervention Hierarchy (Ancestors)

Electrical Equipment and SuppliesEquipment and Supplies

Central Study Contacts

Andrea Goosen

CONTACT

Romina Foster-Bonds

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Model Details: All participants will have a diagnosis of Long COVID-19, Chronic Fatigue Syndrome or Postural Orthostatic Tachycardia Syndrome.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director

Study Record Dates

First Submitted

February 17, 2023

First Posted

February 23, 2023

Study Start

November 16, 2023

Primary Completion

December 1, 2025

Study Completion

December 1, 2025

Last Updated

May 11, 2025

Record last verified: 2025-05

Locations