Identification of Patients at Risk of CKD After AKI

NCT05740709 | Unknown

• 1 other identifier: IRAS 319992
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators will investigate whether new kidney biomarkers can identify patients who are at risk of chronic kidney disease after an episode of moderate / severe acute kidney injury in ICU.

Conditions

Acute Kidney Injury; Kidney Diseases

Keywords

acute kidney injury; chronic kidney disease; kidney biomarkers

Outcome Measures

Primary Outcomes (1)

• serum creatinine

  estimated glomerular filtration rate (eGFR) \<60ml/min

  3 months after discharge from hospital

Secondary Outcomes (3)

• mortality

  90 days

• cardiovascular morbidity

  3 months post hospitalisation

• questionnaire

  3 months post hospitalisation

Study Arms (1)

AKI patients

Patients who suffered from AKI whilst in ICU and are awaiting discharge from hospital

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

critically ill adult patients in the ICU

You may qualify if:

• critically ill adult patients who had AKI stage II or III whilst in ICU and are scheduled to be discharged from hospital

You may not qualify if:

• known pre-existing end-stage kidney disease or advanced CKD (stage 3b or worse)
• kidney transplant within the last 12 months
• known primary renal disease
• discharge from hospital for end-of-life care
• transfer to another health care institution for ongoing in-patient care
• not expected to survive for 3 months
• pregnancy
• lack of capacity to give consent
• receiving regular dialysis at hospital discharge
• CKD stage 3 or worse at hospital discharge

Sponsors & Collaborators

• Guy's and St Thomas' NHS Foundation Trust: lead

Study Sites (1)

Guy's & St Thomas Foundation Hospital

London, SE1 7EH, United Kingdom

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

plasma and urine samples

MeSH Terms

Conditions

Acute Kidney Injury; Kidney Diseases; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Marlies Ostermann, PhD

  Guy's & St Thomas' NHS Foundation Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Marlies Ostermann, PhD

CONTACT

02071887188; Marlies.Ostermann@gstt.nhs.uk

Gill Arbane

CONTACT

02071887188; Gill.Arbane@gstt.nhs.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 10, 2022
• First Posted: February 23, 2023
• Study Start: March 1, 2023
• Primary Completion: January 1, 2025
• Study Completion: January 1, 2026
• Last Updated: January 23, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)