Susceptibility Weighted Imaging for Detection of Thrombus in Acute Ischemic Stroke.

NCT05738070 | Completed

• 1 other identifier: 113/2021
• Study Type: observational
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

It is a retrospective cross-sectional study, where consecutive stroke patients with vessel occlusion on magnetic resonance angiography (MRA) will be included for the study for one year. The relation of Susceptibility vascular sign (SVS) on Susceptibility Weighted Imaging (SWI) with risk factors and territory involved and length of thrombus will correlated with the National Institutes of Health stroke scale (NIHSS).Among total number of patients included in this study the demographics of the patients will be calculated. Risk factors for stroke of the patients included in this study will tabulated. The site of occlusion will be tabulated. The mean NIHSS scale will be calculated. Presence of SVS in patients with MR angiography positive vessel occlusion will be calculate in percentage. Subgroup analysis of presence of SVS on SWI will be done. The mean length of the thrombus will be calculated in these patients with positive SVS. Correlation between SVS on SWI with the risk factor of the patient by using the chi-square test will be calculated. A Chi-square test will be done to find out the correlation between the SVS with territorial occlusion. The correlation between the NIHSS score and length of thrombus will be calculated using the Pearson test. SWI can be useful in identifying the location of the thrombus, and NIHSS can determine the thrombus length in acute stroke. A higher incidence of SVS can be associated with risk factors and it also depends upon the site of occlusion of the vessel.

Conditions

Acute Ischemic Stroke

Keywords

Susceptibility vessel sign (SVS), MR angiography (MRA), thrombus length (TL)

Outcome Measures

Primary Outcomes (5)

• Patients Demographics and risk factor

  Among total number of patients included in this study patients will be assessed as name , age ,sex, risk factor. Risk factors for stroke of the patients included in this study will tabulated such as smoking, heart disease, alcohol etc .

  one year

• Site of occlusion

  The site of occlusion on Magnetic resonance angiography will be tabulated such as Middle cerebral artery, Anterior cerebral artery etc

  one year

• Presence of SVS on SWI

  Presence of Susceptible vascular sign (SVS) on susceptibility weighted imaging (SWI) in patients with MR angiography positive vessel occlusion will be calculate in percentage

  one year

• Sub group analysis for positive susceptible vascular sign

  Subgroup analysis of presence of SVS on SWI will be done as per site of occlusion , risk factor, age ,sex and mean thrombus length

  one year

• Association of Positive SVS on SWI with Different factors

  Chi-square test will be done to find out the correlation between the SVS with territorial occlusion and presence of SVS on SWI with the risk factor.

  one year

Study Arms (1)

Patients with acute ischemic stroke

All the patients with stroke admitted to the hospital from July 2021 to July 2022 were included in this study. Patients with the following criteria were included in the study: (1) anterior circulation stroke established by diffusion-weighted imaging (DWI), (2) MRI performed within 72 hours of stroke onset, (3) Patient with occlusion of the vessel on MRA (Magnetic Resonance Angiography). (4) MRI performed before or during intravenous thrombolysis (IVT) or mechanical thrombectomy (MT). Infarcts with hemor¬rhagic transformation cases were not included in the study due to suboptimal SVS quantification

Diagnostic Test: Magnetic resonance imaging

Interventions

Magnetic resonance imaging DIAGNOSTIC_TEST

MRI was done in 1.5T unit (Siemens, Magnetom, Essenza). Different parameters for SWI as follows at 1.5T: echo time (TE) = 40 ms, repetition time (TR) = 29 ms, slice thickness = 0.7 mm, flip angle = 25°, field of view (FOV) = 184 × 200, intersection gap = 0 mm, and matrix size = 322 × 225. MRA parameters were as follows: TR = 29 ms, TE = 7.15 ms, FOV = 168 × 200 mm, slice thickness = 0.7 mm, flip angle = 25°, with acquisition time of 3 minutes.

Patients with acute ischemic stroke

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All the patients with stroke admitted to the hospital from July 2021 to July 2022 were included in this study.

You may qualify if:

• Anterior circulation stroke established by diffusion-weighted imaging (DWI),
• MRI performed within 72 hours of stroke onset,
• Patient with occlusion of the vessel on MRA (Magnetic Resonance Angiography).
• MRI performed before or during intravenous thrombolysis (IVT) or mechanical thrombectomy (MT).

You may not qualify if:

• Infarcts with hemorrhagic transformation cases were not included in the study due to suboptimal SVS quantification.

Sponsors & Collaborators

• Upendra Devokta Memorial National Institute of Neurology and Allied Scicences: lead

Study Sites (1)

Sushanta Paudel

Bharatpur, Bagmati, 44600, Nepal

Location

Related Publications (1)

• Halefoglu AM, Yousem DM. Susceptibility weighted imaging: Clinical applications and future directions. World J Radiol. 2018 Apr 28;10(4):30-45. doi: 10.4329/wjr.v10.i4.30.

  PMID: 29849962 BACKGROUND

MeSH Terms

Conditions

Ischemic Stroke

Interventions

Magnetic Resonance Imaging

Condition Hierarchy (Ancestors)

Stroke; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Tomography; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Sushanta Paudel

Study Record Dates

• First Submitted: January 19, 2023
• First Posted: February 21, 2023
• Study Start: July 1, 2021
• Primary Completion: July 1, 2022
• Study Completion: December 20, 2022
• Last Updated: February 21, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

NE (1)