NCT05727137

Brief Summary

This study will compare the analgesic efficacy of daily single-shot adductor canal block(ABC) versus continuous ACB after total knee arthroplasty (TKA).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable postoperative-pain

Timeline
Completed

Started Feb 2023

Typical duration for not_applicable postoperative-pain

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 25, 2023

Completed
20 days until next milestone

First Posted

Study publicly available on registry

February 14, 2023

Completed
7 days until next milestone

Study Start

First participant enrolled

February 21, 2023

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 27, 2023

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 8, 2024

Completed
Last Updated

April 12, 2024

Status Verified

April 1, 2024

Enrollment Period

8 months

First QC Date

January 25, 2023

Last Update Submit

April 11, 2024

Conditions

Postoperative Pain

Outcome Measures

Primary Outcomes (1)

  • Average NRS pain score at rest

    average of numerical rating scale (0: no pain, 10: worst imaginable pain) pain scores from 8 time points during 48h (+4h, +8h, +12h from end of surgery, 6AM, 2PM, 10PM of postoperative day 1, and 6AM and 2PM of postoperative day 2)

    first 48h after end of surgery

Secondary Outcomes (24)

  • numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +4h from end of surgery

    +4h from end of surgery

  • numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +4h from end of surgery

    +4h from end of surgery

  • NRS pain score at rest at +8h from end of surgery

    +8h from end of surgery

  • numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +8h from end of surgery

    +8h from end of surgery

  • numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +12h from end of surgery

    +12h from end of surgery

  • +19 more secondary outcomes

Study Arms (2)

Single shot adductor canal block

EXPERIMENTAL
Procedure: Single shot adductor canal block

Continuous adductor canal block

ACTIVE COMPARATOR
Procedure: Continuous adductor canal block

Interventions

Single shot adductor canal blockPROCEDURE

Single shot adductor canal block on the the first and second postoperative day.

Single shot adductor canal block
Continuous adductor canal blockPROCEDURE

A catheter will be placed in the adductor canal and connected to a continuous patient-controlled analgesia pump.

Continuous adductor canal block

Eligibility Criteria

Age19 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ASA classification I, II, III
  • Patients scheduled for unilateral knee arthroplasty

You may not qualify if:

  • Anesthesia other than spinal anesthesia
  • Chronic opioid use
  • Uncontrolled diabetes of HbA1c\>7.5
  • Neuromuscular pathology of the ipsilateral leg
  • Second-look knee arthroplasty
  • Inability to communicate (e.g. dementia)
  • Hypersensitivity to ropivacaine
  • BMI \> 40
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

Location

Related Publications (1)

  • Kim H, Yoo S, Kwon S, Kim Y, Bae J, Kim YJ, Cho YJ, Kim JT, Lim YJ. Analgesic Efficacy of Repeated Daily Injections Versus Continuous Adductor Canal Block After Total Knee Arthroplasty: An Open-Label, Randomized Clinical Trial. Anesth Analg. 2026 Jan 1;142(1):132-139. doi: 10.1213/ANE.0000000000007427. Epub 2025 Feb 18.

    PMID: 39964911DERIVED

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Study Officials

  • Seokha Yoo, MD

    Seoul National University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical assistant professor

Study Record Dates

First Submitted

January 25, 2023

First Posted

February 14, 2023

Study Start

February 21, 2023

Primary Completion

October 27, 2023

Study Completion

March 8, 2024

Last Updated

April 12, 2024

Record last verified: 2024-04

Locations

KR(1)