Volatile Non-Invasive Biomarkers of Epileptic Seizures

NCT05725174 | Recruiting

• 2 other identifiers: 28591322/LO/0808
• Study Type: observational
• Target: 270
• Locations: 1 country
• Sites: 2

Brief Summary

Breath and sweat samples will be collected from people who have been admitted to hospital after a potential seizure and analysed by the team. The researchers then hope to identify a pattern of small molecules that can distinguish seizures from other events, and perhaps determine the severity of the seizure.

Conditions

Epilepsy; Non-Epileptic Seizure

Outcome Measures

Primary Outcomes (1)

• Distinguishing epileptic from non-epileptic seizures

  To distinguish epileptic from non-epileptic seizures with the detection of volatile organic compounds (VOCs) in breath and sebum samples.

  3 years

Interventions

Sample Collection OTHER

Patients will have breath samples collected by blowing into a bag, and sweat samples collected by gauze. These samples will be collected at various timepoints whilst the patients are admitted on the ward.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People with a diagnosis of epileptic or non-epileptic seizures

You may qualify if:

• Patients who have been admitted to either University College London's Queen's Square EEG-telemetry unit or Chalfont Centre for Epilepsy, for diagnosis of seizure events.
• Patients aged 18 years or above

You may not qualify if:

• Patients with active infection or who have taken antibiotics within 4 weeks
• Patients on immunosuppressive medications
• Patients with co-morbidities preventing breath collection
• Patients unable to provide informed consent.

Sponsors & Collaborators

• University College London Hospitals: lead
• Imperial College London: collaborator

Study Sites (2)

Chalfont Centre for Epilepsy

London, Buckinghamshire, SL9 0RJ, United Kingdom

RECRUITING

National Hospital for Neurology and Neurosurgery

London, London, WC1N 3BG, United Kingdom

RECRUITING

MeSH Terms

Conditions

Epilepsy; Seizures

Interventions

Specimen Handling

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Matthew Walker, MB BChir FRCP

  Professor

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Eleonora Lugara, PhD

CONTACT

02031089108; e.lugara@ucl.ac.uk

Grace Luff, MSc

CONTACT

g.luff@ucl.ac.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: February 2, 2023
• First Posted: February 13, 2023
• Study Start: January 30, 2023
• Primary Completion: October 1, 2025
• Study Completion (Estimated): November 1, 2026
• Last Updated: December 6, 2024

Record last verified: 2024-12

Locations

GB (2)