Gene-environment Interactions in Families With Adolescents (Gen-omgevingsinteracties in Gezinnen Met Adolescenten)

NCT05716412 | Completed

• 1 other identifier: S56106
• Study Type: observational
• Target: 1,326
• Locations: 1 country
• Sites: 2

Brief Summary

English: The main purpose of this study is to investigate the developmental trajectories of parents and adolescents in the Flemish region of Belgium. The investigators will focus on the role of genetic factors, environmental factors (e.g. parental rearing styles), and the interaction between these factors. Specifically, it will be investigated were difficulties or strengths in the development of adolescents can be attributed to. How an individual's genetic characteristics and his/her family environment can interact, will also be monitored. This study is closely related to the Leuvense Adoption Study (http://leuvenseadoptiestudie.be/). Just like this research, the investigators will take child and parent factors in account, as well as their interaction. The investigators will not only focus on vulnerability, but also on protective factors that can give resilience to both parents and children. The theoretical framework of this study is twofold. (1) In the development of children, genes and environment are interwoven in a dynamical relation. Neither genes or environment alone can explain how a child will develop over time. (2) The relation between genetic and environmental factors can be expressed in different ways. On the one hand, a certain genetic contribution can impact the way parents will uphold a certain parental rearing style. On the other hand, having certain genetic characteristics will have consequences for how adolescents will react to their environment. For example, a certain parental rearing style will strengthen some adolescents resilience, but for other adolescents this could equally lead to a more maladaptive development. Thus, depending on his or her genetic endowment, a child will develop differently given a certain family environment.

Conditions

Affective Spectrum Symptoms

Outcome Measures

Primary Outcomes (1)

• Beck's Depression Inventory / Children's Depression Inventory

  Dimensional assessment and cut-off scores using Beck's Depression Inventory for the adults and Kovacs' Children's Depression Inventory for the adolescents.

  current symptoms, measured once after enrollment

Secondary Outcomes (2)

• Somatic Symptoms Questionnaire

  current complaints, measured once after enrollment

• Depressive Experiences Questionnaire: self-criticism and dependency

  measured once after enrollment

Study Arms (3)

Adopted adolescents and their adoptive parents

Adopted before the age of one, currently between 12 to 18 years old

Adolescents and their biological related parents

Matched to adoptive adolescents

Additional community sample

Eligibility Criteria

• Age: 12 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adopted adolescents and their parents, adolescents with their biological parents, and an additional community sample.

You may qualify if:

• Adolescents adopted before the age of one and currently 12 to 18 years old (from international adoption) and their adoptive parents
• Matched community sample of adolescents between the age of 12 and 18 years old and their biological related parents

You may not qualify if:

• Major medical or psychiatric disease

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead
• Fund for Scientific Research, Flanders, Belgium: collaborator

Study Sites (2)

University of Gent - Faculty of Psychology and Educational Sciences - Department of Developmental-, Personality- and Social Psychology

Ghent, Oost-Vlaanderen, 9000, Belgium

Location

KU Leuven - Department of Psychology and Educational Sciences - Clinical Psychology Research Unit

Leuven, Vlaams-Brabant, 3000, Belgium

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva

Study Officials

• Patrick Luyten, Prof. Dr.

  KU Leuven - Faculty of Psychology and Educational Sciences - Clinical Psychology Research Unit

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2014
• First Posted: February 8, 2023
• Study Start: September 1, 2014
• Primary Completion: February 1, 2017
• Study Completion: February 1, 2017
• Last Updated: February 8, 2023

Record last verified: 2016-05

Locations

BE (2)