Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts

NCT05712811 | Completed

• 1 other identifier: CMHAbbottabad
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts. Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from Jun 2022 to Nov, 2022.

Conditions

Warts

Outcome Measures

Primary Outcomes (1)

• Comparison of cryotherapy and Tricholoracetic acid 90% in treatment of common warts

  Outcome was determined at the end of third month and the patients were labelled as cured and the efficacy was labelled as "Yes" in cases with absence of all the lesions. After twelve weeks of therapy, individuals with persistent warts were regarded as cases of treatment failure and efficacy was labelled as "No".

  12 weeks

Study Arms (2)

Group A cryotherapy

ACTIVE COMPARATOR

Cryotherapy Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).

Drug: CRYOTHERAPY

Group B Topical TCA 90%

ACTIVE COMPARATOR

Topical TCA 90 % Warts in Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline

Drug: Tricholoracetic acid

Interventions

CRYOTHERAPY DRUG

Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).

Also known as: Liquid nitrogen

Group A cryotherapy

Tricholoracetic acid DRUG

Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline.

Also known as: Peeling agent

Group B Topical TCA 90%

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patient presented with common warts in dermatology opd

You may not qualify if:

• Patients with warts on toes and tip of fingers
• genital warts
• cardiac, hepatic and renal disease
• hypercholesterolemia
• hypersensitivity reactions

Sponsors & Collaborators

• Combined Military Hospital Abbottabad: lead

Study Sites (1)

Cmh abbottabad

Abbottābād, Kpk, 22010, Pakistan

Location

MeSH Terms

Conditions

Warts

Interventions

Cryotherapy

Condition Hierarchy (Ancestors)

Papillomavirus Infections; DNA Virus Infections; Virus Diseases; Infections; Skin Diseases, Viral; Tumor Virus Infections; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Therapeutics

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: January 18, 2023
• First Posted: February 6, 2023
• Study Start: June 1, 2022
• Primary Completion: November 30, 2022
• Study Completion: November 30, 2022
• Last Updated: February 6, 2023

Record last verified: 2023-01

Locations

PA (1)