Cortical Processes During Walking Post-stroke

NCT05710029 | Completed

• 1 other identifier: IRB202202100
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to use novel mobile imaging techniques with high-density electroencephalography (EEG) to quantify cortical processes synchronized to the biomechanics of walking. Here, the study has two aims - the primary aim is to quantify the cortical processes that contribute to gait dysfunction early post-stroke, and the second aim is to determine how cortical processes are mediated by mechanical assistance during early gait training post-stroke. Participants will wear an electroencephalography (EEG) cap to measure brain activity and other non-invasive physiological sensors. Participants will be asked to perform different tasks, such as walking at different speeds and walking with different levels of body weight support.

Conditions

Stroke, Acute; Walking, Difficulty

Keywords

Walking; Stroke; EEG; Assistance

Outcome Measures

Primary Outcomes (2)

• Brain activity during walking measured by EEG

  Changes in brain activity during walking with different levels of weight support

  through study study completion, an average of 2 years

• Brain activity during walking measured by EEG

  Differences in brain activity during walking between people post-stroke and neurotypical individuals

  through study study completion, an average of 2 years

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Post-stroke participants (age 18-80), age-matched adults (age 18-80)

You may qualify if:

• Participants will have a unilateral brain lesion within six months prior to participation in this project;
• Paresis confined to one side;
• Ability to walk for 10 meters continuously;
• Absence of severe cognitive dysfunction as demonstrated by a Mini-Mental score greater than 24;
• Absence of severe concurrent medical problems;
• Ability to provide informed consent.

You may not qualify if:

• Any major neurological, cardiovascular, orthopedic, and psychiatric diagnoses

Sponsors & Collaborators

• University of Florida: lead

Study Sites (1)

University of Florida

Gainesville, Florida, 32610, United States

Location

MeSH Terms

Conditions

Stroke; Mobility Limitation; Helping Behavior

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Social Behavior; Behavior

Study Officials

• Chang Liu, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

• Daniel Ferris, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

• Dorian Rose, PT, PhD

  University of Florida

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2023
• First Posted: February 2, 2023
• Study Start: May 1, 2023
• Primary Completion: June 30, 2024
• Study Completion: June 30, 2024
• Last Updated: April 1, 2025

Record last verified: 2025-03

Locations

US (1)