Modelling and Control of Non-invasive Vagus Nerve Stimulation for Autoimmune Diseases (1A)

You may not qualify if:

• Treatment with rituximab within one year of baseline as it is related to lymphocyte depletion that could alter the result of the biomarker study (subjects with previous treatment with rituximab can enter study only with documentation of B cell repletion).
• Treatment with cyclophosphamide within 2 months of baseline as it is related to lymphocyte depletion that could alter the result of the biomarker study.
• Expectation to increase steroids and/or immunosuppressive treatment.
• Anti-phospholipid syndrome.
• Fibromyalgia (fibromyalgia will be defined as a score \> 13 on the Fibromyalgia Symptom Scale), chronic fatigue syndrome.
• Treatment with an anti-cholinergic or sympathicomimetic medication, including over the counter medications.
• Implantable electronic devices such as pacemakers, defibrillators, hearing aids, cochlear implants or deep brain stimulators.
• Joint replacement within 60 days prior to study enrolment or planned within the course of the study.
• Any planned surgical procedure requiring general anaesthesia within the course of the study.
• Intra-articular cortisone injections within 28 days of the start of study.
• Chronic inflammatory disorders apart from SLE affecting the joints.
• Investigational drug and/or treatment during the 28 days or seven half-lives of the investigational drug prior to the start of study drug dosing (Day 0), whichever is the greater length of time.
• Active infection including hepatitis B, hepatitis C or HIV at baseline due to high prevalence of neuropathy.
• Any condition which, in the opinion of the investigator, would jeopardize the subject's safety following exposure to a study intervention.
• Pregnancy or lactation.
• +6 more criteria