Prevalence and Comorbidities of Dermatoporosis: a French Prospective Observational Study in General Medicine Consultation

NCT05699980 | Completed

• 1 other identifier: University of Lorraine
• Study Type: observational
• Target: 370
• Locations: 1 country
• Sites: 15

Brief Summary

The term dermatoporosis (DP) was proposed by JH. Saurat in 2004 and detailed in 2007 to describe a chronic cutaneous insufficiency and fragility syndrome. The concept of DP, the positive diagnosis and the complications are well identified in the literature. However, while the consequences of skin aging are a growing concern, knowledge of DP is stagnant. DP is clinically defined by the combination of three clinical signs: skin atrophy, white pseudo-scars, and senile purpura. It mainly sits on photo-exposed regions: posterior face of the forearms and back of the hands in 92 to 100% of cases; but also the pre-tibial, pre-sternal, and cephalic regions. DP appears at around 60 years old and can worsen with advancing age. Complications of varying severity can occur during its development: skin tears, delayed healing, infection, hematomas including dissecting hematomas that are sometimes life-threatening. DP is classified into four stages defined in 2004 and revised in 2012. The autonomy of the DP entity or its integration as a marker in multi-organ failure has not yet been determined. It is a condition on the borders of several specialties requiring good coordination between them (dermatologists, general practitioners, geriatricians, nurses, etc.) The few published epidemiological studies report a prevalence ranging from 4% to 37.5% in patients aged 50 years and over. These epidemiological data are very heterogeneous (age of recruitment, patients hospitalized or seen on an outpatient basis in consultations of different specialties, sample of the population, etc.). Among these studies, three clinical studies, two on a French hospital cohort, the other on outpatients in Dermatology in Finland, estimated the prevalence of DP between 27 and 32% in adults aged 60 years and older. In all three studies, DP was associated with advanced age, with a risk of DP up to double in patients aged 85 and older compared to younger patients. In two of these studies, a link was suggested with the status of chronic renal failure, either independently for one, or concomitant with taking anticoagulants and corticosteroids for the other. For Kluger et al., DP was also associated with the independent use of very strong local or systemic corticosteroids. For Chanca et al., an independent link between DP and tobacco consumption, taking anticoagulant treatment, and chronic recreational sun exposure has been observed.

Conditions

Dermatoporosis

Keywords

skin ageing; sun exposure; skin tears; purpura

Outcome Measures

Primary Outcomes (1)

• Presence or absence of dermatoporosis on the forearms or back of the hands

  Presence or absence of dermatoporosis on the forearms or back of the hands in patients aged 60 or over in general practice

  At admission, Day 1

Secondary Outcomes (11)

• Measurement of phototype

  At admission, Day 1

• Childhood sun exposure

  At admission, Day 1

• Lifetime sun exposure Measurement of phototype

  At admission, Day 1

• Tobacco consumption

  At admission, Day 1

• Presence or absence of diabetes

  At admission, Day 1

Study Arms (1)

Patient aged 60 or over presenting to their general practitioner

Patient aged 60 or over presenting to his general practitioner (among the 20 general practitioners recruited in Lorraine (eastern France))

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients aged 60 or over presenting to their general practitioner.

You may qualify if:

• Patient presenting to his general practitioner
• Patient aged 60 or over

You may not qualify if:

• Refusal of participation

Sponsors & Collaborators

• University of Lorraine: lead
• Study Director: Anne Claire Bursztejn, PHD-MD, CHU Nancy - University of Lorraine: collaborator
• Study Chair: Christophe Goetz, MD, CHR Metz-Thionville - University of Lorraine: collaborator

Study Sites (15)

Stéphanie Chevalier

Ancerville, 55170, France

Location

Wissam Al Shouaib

Basse-Ham, 57970, France

Location

Sophie LARUELLE

Bénaménil, 54450, France

Location

Sophie Delaporte

Bulgnéville, 88140, France

Location

Cédric Berbé

Cattenom, 57570, France

Location

Sandra Pacini

Hayange, 57700, France

Location

Anais Leclerc

Hettange-Grande, 57330, France

Location

Benoit Nicolas

Hettange-Grande, 57330, France

Location

Mathieu Zimmermann

Le Val-dAjol, 88340, France

Location

Mélanie Damervalle

Longuyon, 54260, France

Location

Patrick Vauthier

Longwy, 54400, France

Location

Aurelie François

Raon-l'Étape, 88110, France

Location

Jean-Louis Autissier

Thaon-les-Vosges, 88150, France

Location

Cabinet Tronville en Barrois

Tronville-en-Barrois, 55310, France

Location

Cabinet Varangéville

Varangéville, 54110, France

Location

Related Publications (4)

• Kaya G, Saurat JH. Dermatoporosis: a chronic cutaneous insufficiency/fragility syndrome. Clinicopathological features, mechanisms, prevention and potential treatments. Dermatology. 2007;215(4):284-94. doi: 10.1159/000107621.

  PMID: 17911985 BACKGROUND

• Mengeaud V, Dautezac-Vieu C, Josse G, Vellas B, Schmitt AM. Prevalence of dermatoporosis in elderly French hospital in-patients: a cross-sectional study. Br J Dermatol. 2012 Feb;166(2):442-3. doi: 10.1111/j.1365-2133.2011.10534.x. Epub 2011 Dec 5. No abstract available.

  PMID: 21787367 BACKGROUND

• Chanca L, Fontaine J, Kerever S, Feneche Y, Forasassi C, Meaume S, Colboc H. Prevalence and risk factors of dermatoporosis in older adults in a rehabilitation hospital. J Am Geriatr Soc. 2022 Apr;70(4):1252-1256. doi: 10.1111/jgs.17618. Epub 2021 Dec 17.

  PMID: 34918778 BACKGROUND

• Kluger N, Impivaara S. Prevalence of and risk factors for dermatoporosis: a prospective observational study of dermatology outpatients in a Finnish tertiary care hospital. J Eur Acad Dermatol Venereol. 2019 Feb;33(2):447-450. doi: 10.1111/jdv.15240. Epub 2018 Oct 1.

  PMID: 30198583 BACKGROUND

MeSH Terms

Conditions

Purpura

Condition Hierarchy (Ancestors)

Blood Coagulation Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Skin Manifestations; Signs and Symptoms

Study Officials

• Antoine Truchetet, MD

  University of Lorraine

  PRINCIPAL INVESTIGATOR

• Anne Claire Bursztejn, PHD-MD

  CHU Nancy - University of Lorraine

  STUDY DIRECTOR

• Cédric Berbé, MD

  University of Lorraine

  STUDY DIRECTOR

• Christophe Goetz, MD

  CHR Metz-Thionville - University of Lorraine

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator, MD

Study Record Dates

• First Submitted: January 17, 2023
• First Posted: January 26, 2023
• Study Start: May 23, 2022
• Primary Completion: May 23, 2022
• Study Completion: October 3, 2022
• Last Updated: May 1, 2023

Record last verified: 2023-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (15)