Yttrium-90 Carbon Microspheres in Patients With Unresectable Colorectal Liver Metastases

NCT05692037 | Unknown Phase 1

• 1 other identifier: CHANCE2303-NRT6003
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the efficacy and safety of yttrium-90 carbon microspheres in patients with unresectable colorectal liver metastases

Conditions

Unresectable Colorectal Liver Metastases

Outcome Measures

Primary Outcomes (1)

• Progression Free Survival Rate of Liver Target Lesions

  Survival probability of patients without imaging progression of liver target lesions

  3 months after yttrium-90 injection

Secondary Outcomes (9)

• Adverse events

  Up to 24 months

• Yttrium-90 distribution

  Within 24 hours

• Objective response rate (ORR)

  Up to 24 months

• Duration of response (DOR)

  Up to 24 months

• Hepatic progression-free survival (hPFS)

  Up to 24 months

Study Arms (1)

Yttrium-90 carbon microspheres

EXPERIMENTAL

Single dose of yttrium-90 carbon microspheres injection. Patients will be assessed by SPECT-CT imaging within 24 hours for yttrium-90 distribution in the chest and upper abdomen, including extrahepatic shunts, intrahepatic distribution, and target lesion distribution as expected.Ten Patients will be tested for the radioactivity of yttrium-90 in blood, urine, and feces (if available).

Combination Product: Selective internal radiation therapy (SIRT) with yttrium-90 carbon microspheres

Interventions

Selective internal radiation therapy (SIRT) with yttrium-90 carbon microspheres COMBINATION_PRODUCT

Yttrium-90 carbon microspheres SIRT

Yttrium-90 carbon microspheres

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Eastern Cooperative Oncology Group performance status ≤ 1;
• Expected survival time ≥ 3 months;
• Confirmed liver metastasis of colorectal cancer;
• Complete resection and no local recurrence of the primary colorectal cancer;
• Intolerance, failure to the previous anti-tumor treatments or, or recurrence liver metastasis after surgical resection;
• Without extrahepatic metastases, inoperable or refuse surgical resection;
• At least one well defined tumor (RECIST 1.1);
• Tumor burden ≤ 50% of the total liver volume;
• Child-Pugh score ≤ 7;
• Adequate organ function: ① Blood routine \[no blood transfusion or colony-stimulating factor (G-CSF) treatment within 14 days\]: absolute neutrophil count ≥ 1.5 × 109/L; platelet ≥ 75 × 109/L; hemoglobin ≥ 90 g/L; ② Liver function: total bilirubin ≤ 2 times upper limit of normal (ULN); alanine transaminase and aspartate aminotransferase ≤ 5. 0 ULN; alkaline phosphatase ≤ 2.5 ULN; Albumin \> 30 g/L; ③ Renal function: Cr ≤ 1.5 ULN; creatinine clearance ≥ 50 mL/min (calculated according to Cockcroft-Gault formula); ④ Coagulation function: international normalized ratio, prothrombin time and activated partial thromboplastin time were less than 1.5 ULN; ⑤ Cardiovascular function: left ventricular ejection fraction ≥ 50%;
• According to CTCAE 5.0 standard, all adverse events of previous systematic anti-cancer treatment have recovered to baseline or ≤ 1 grade, \[except for the following: neuropathy induced by previous anti-cancer treatment is stable (≤ 2 grade) and hair loss\];
• Women and men of childbearing age must agree to take strict and effective contraceptive measures during the study period and within 6 m after the end of the trial. Men are forbidden to donate sperm. The pregnancy test results of female patients of childbearing age during the screening period and within 24 hours before administration must be negative.

You may not qualify if:

• With previous history of hepatic encephalopathy;
• Severe pulmonary insufficiency (forced expiratory volume at one second / forced vital capacity \< 50% or forced expiratory volume at one second /predicting value \< 50% or maximum volume per minute \< 50 L/min);Obvious chronic obstructive pulmonary disease or interstitial pneumonia;
• Percentage of hepatopulmonary shunt \> 10%, or the single lung radiation absorbed dose \> 30 Gy;
• With hepatic artery malformation and unable to intubate hepatic artery;
• Tumor thrombus in main portal vein;
• Have received radiotherapy or transcatheter arterial chemoembolization (patients who have received transcatheter arterial non-iodized oil chemoembolization are judged by researchers);
• The last anti-tumor treatment (surgery, chemotherapy, immunotherapy, targeted therapy) was less than 4 weeks before the drug administration;
• Clinical manifestations of portal hypertension, moderate-severe or refractory ascites, or decompensated liver cirrhosis;
• Major surgery or severe trauma within 28 days before yttrium-90 administration;
• Participated in other trial within 1 month before yttrium-90 administration;
• Pregnant and lactating women;
• Serious infections in active stage or need systematic treatment;
• With positive results of HIV antibody test;
• The researchers judge that there is unresolved toxicity from previous treatment and will continue to exist, which may endanger the safety of patients;
• The researcher judged clinical or laboratory examination abnormality or other reasons.

Sponsors & Collaborators

• Zhongda Hospital: lead

Study Sites (1)

Zhongda Hospital Southeast University

Nanjing, Jiangsu, 100730, China

RECRUITING

MeSH Terms

Interventions

Sirtuins

Intervention Hierarchy (Ancestors)

Group III Histone Deacetylases; Histone Deacetylases; Amidohydrolases; Hydrolases; Enzymes; Enzymes and Coenzymes; ADP Ribose Transferases; Pentosyltransferases; Glycosyltransferases; Transferases; Intracellular Signaling Peptides and Proteins; Proteins; Amino Acids, Peptides, and Proteins

Study Officials

• Gao-Jun Teng, MD

  Zhongda Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hai-Dong Zhu, MD

CONTACT

+862583262224; zhuhaidong9509@163.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dean

Study Record Dates

• First Submitted: December 25, 2022
• First Posted: January 20, 2023
• Study Start: December 28, 2022
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: January 30, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)