NCT05687994

Brief Summary

The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 9, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 18, 2023

Completed
7 days until next milestone

Study Start

First participant enrolled

January 25, 2023

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 29, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 29, 2025

Completed
Last Updated

September 18, 2025

Status Verified

September 1, 2025

Enrollment Period

2.3 years

First QC Date

January 9, 2023

Last Update Submit

September 12, 2025

Conditions

Aphasia, Acquired

Outcome Measures

Primary Outcomes (1)

  • Correct Information Units per Minute

    Correct Information Units per Minute will be tallied by blinded coders to measure the informativeness and efficacy of speech

    one day post treatment

Secondary Outcomes (1)

  • Number of Different Words per Minute

    one day post treatment

Study Arms (2)

Audiovisual Speech Entrainment Practice

EXPERIMENTAL

Audiovisual Speech Entrainment includes repeated practice of speaking synchronously with a recorded model, which provides contextual, temporal, and audiovisual cues for speaking.

Behavioral: Audiovisual Speech Entrainment PracticeBehavioral: Auditory Speech Entrainment Practice

Auditory Speech Entrainment Practice

EXPERIMENTAL

Auditory Speech Entrainment includes repeated practice of speaking synchronously with a recorded model, which provides contextual, temporal, and auditory cues for speaking.

Behavioral: Audiovisual Speech Entrainment PracticeBehavioral: Auditory Speech Entrainment Practice

Interventions

Audiovisual Speech Entrainment PracticeBEHAVIORAL

Speech Entrainment Practice is an aphasia rehabilitation treatment based on imitation of recorded speech in real time. Treatment includes repeated practice of speaking along with a recorded model, which provides contextual, temporal, auditory, and visual cues for speaking

Audiovisual Speech Entrainment PracticeAuditory Speech Entrainment Practice
Auditory Speech Entrainment PracticeBEHAVIORAL

Speech Entrainment Practice is an aphasia rehabilitation treatment based on imitation of recorded speech in real time. Treatment includes repeated practice of speaking along with a recorded model, which provides contextual, temporal, and auditory cues for speaking

Audiovisual Speech Entrainment PracticeAuditory Speech Entrainment Practice

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between 18-80 years at the time of enrollment
  • English as native language
  • greater than six months post onset
  • Diagnosis of aphasia based on Western Aphasia Battery - Revised (WAB-R)
  • Score of 7 or less on the Fluency subsection of the WAB-R
  • Demonstrate having the willingness and stamina to participate in the multiple-session protocol, either by traveling to the MRRI testing site or being tested at home

You may not qualify if:

  • History of learning disabilities
  • History of other comorbid neurological impairments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Moss Rehabilitation Research Institute

Elkins Park, Pennsylvania, 19027, United States

Location

MeSH Terms

Conditions

Aphasia

Condition Hierarchy (Ancestors)

Speech DisordersLanguage DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Marja-Liisa Mailend, PhD

    Albert Einstein Healthcare Network

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Institute Scientist

Study Record Dates

First Submitted

January 9, 2023

First Posted

January 18, 2023

Study Start

January 25, 2023

Primary Completion

May 29, 2025

Study Completion

May 29, 2025

Last Updated

September 18, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations

US(1)