Two Patterns of Micropulse Laser in the Treatment of Chronic Central Serous Chorioretinopathy

NCT05687422 | Unknown

• 1 other identifier: 2021-I2M-C&T-B-093
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Central serous chorioretinopathy (CSC) is a common eye disease mainly involving the macular area, causing central visual acuity loss. Recently, subthreshold micropulse laser used in treating chronic CSC is proved to be safe and effective. However, some studies indicate that it's less effective than half dose photodynamic therapy (PDT). Certain physicians, including us, think that this may be related to micropulse laser parameters. Thus we need to explore better laser patterns to replace PDT in treating chronic CSC. The aim of this study is to compare the treatment effect of two different patterns of laser parameters (small and regular spot diameter) in treating chronic CSC. In this randomized, double blinded, controlled trial, by comparing the subretinal fluid regression ratio, central retinal thickness, macular microvisual field, macular vascular density, chroidal volume changes and visual acuity of two groups 6 months after micropulse laser treatment, we aim to evaluate the safety and efficacy of refined micropulse laser in treating chronic CSC.

Conditions

Central Serous Chorioretinopathy

Outcome Measures

Primary Outcomes (2)

• Subretinal fluid regression ratio

  Comparing the subretinal fluid regression ratio of two groups at 6 months follow-up

  6 months

• Central retinal thickness changes

  Comparing the central retinal thickness changes of two groups at 6 months

  6 months

Study Arms (2)

100μm laser spot diameter group

EXPERIMENTAL

Procedure: 100μm laser spot diameter micropulse laser

200μm laser spot diameter group

ACTIVE COMPARATOR

Procedure: 200μm laser spot diameter micropulse laser

Interventions

100μm laser spot diameter micropulse laser PROCEDURE

100μm laser spot diameter micropulse laser at baseline, then follow-up for 6 months

100μm laser spot diameter group

200μm laser spot diameter micropulse laser PROCEDURE

200μm laser spot diameter micropulse laser at baseline, then follow-up for 6 months

200μm laser spot diameter group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients age range 18-50 years
• Patients diagnosed with chronic Central serous chorioretinopathy
• Patients have signed informed consent

You may not qualify if:

• A history of other fundus diseases or refractive media opacity
• Patients have underwent other treatment methods for chronic Central serous chorioretinopathy
• Diopter\>-6D
• A history of system diseases such as hypertension or diabetes
• A history of using local or systemic corticosteroids

Sponsors & Collaborators

• Beijing Hospital: lead

Related Publications (1)

• Zhang Y, Wang J, Liu J, Gu X, Song S, Yu X. Three-dimensional choroidal characteristics in different subtypes of central serous chorioretinopathy using swept-source optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2025 Mar;263(3):689-697. doi: 10.1007/s00417-024-06691-8. Epub 2024 Nov 19.

  PMID: 39557692 DERIVED

MeSH Terms

Conditions

Central Serous Chorioretinopathy

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: December 25, 2022
• First Posted: January 18, 2023
• Study Start: February 1, 2023
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: January 18, 2023

Record last verified: 2023-01