Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis

NCT05686772 | Completed

• 1 other identifier: 2020-OJUR-286304
• Study Type: observational
• Target: 520
• Locations: 1 country
• Sites: 2

Brief Summary

The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis. The main questions to be answered are:

• Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment);
• Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders);
• Antipsychotic use (first/second-generation, third-generation \[aripiprazole, brexpiprazole, cariprazine\]);
• Prior gambling history.

Conditions

Gambling Disorder; Psychotic Disorders

Keywords

Gambling; Psychotic disorder; Schizophrenia; Cohort; Multicenter; Prospective; Observational; Incidence; Risk factors

Outcome Measures

Primary Outcomes (1)

• Problem gambling

  i) Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist, and/or; ii) Problem gambling according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager and/or treating psychiatrist

  Outcome assessed at every 6-month time point, from patients admission until the first occurrence of the primary outcome, loss to follow-up, or May 1, 2023.

Other Outcomes (1)

• Sensitivity analysis restricted to DSM-5 gambling disorder

  Outcome assessed at every 6-month time point, from patients admission until the first occurrence of the primary outcome, loss to follow-up, or May 1, 2023.

Study Arms (1)

First-episode psychosis patients

All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.

Drug: Antipsychotic use; Other: Psychiatric comorbidities; Other: Sociodemographics/socioeconomic status; Other: Gambling history; Other: Clinical variables

Interventions

Antipsychotic use DRUG

Use of first/second generation antipsychotics, use of third-generation antipsychotics, use of aripiprazole specifically

First-episode psychosis patients

Psychiatric comorbidities OTHER

Substance use disorders, cluster B personality disorders, anxiety disorder, major depressive disorder, attention-deficit/hyperactivity disorder, tobacco smoking

First-episode psychosis patients

Sociodemographics/socioeconomic status OTHER

Age, gender identity, ethnicity, highest educational attainment, employment, at school, homelessness, in a relationship

First-episode psychosis patients

Gambling history OTHER

Non-problematic gambling at the time of admission and/or previous 12 months

First-episode psychosis patients

Clinical variables OTHER

Main psychiatric diagnosis, history of psychiatric hospitalizations, severity of illness (CGI-S), functioning (SOFAS), concomitant psychotropic medications use

First-episode psychosis patients

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All patients meeting the inclusion/exclusion criteria admitted to 2 first-episode psychosis programs located in Quebec (Canada) during the study period (i.e., November 1st, 2019 - May 1st, 2023).

You may qualify if:

• to 35 years old;
• Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).

You may not qualify if:

• Active/prior PBG at te time of admission;
• Loss to follow-up within first three months;
• DSM-5 diagnosis of psychotic disorder due to a medical condition;
• Severe intellectual disability.

Sponsors & Collaborators

• Laval University: lead
• Fonds de la Recherche en Santé du Québec: collaborator

Study Sites (2)

Montreal University Hospital Center

Montreal, Quebec, H2X 3E4, Canada

Location

Quebec Mental Health University Institute

Québec, Quebec, G1J 2G3, Canada

Location

Related Publications (7)

• Corbeil O, Corbeil S, Dorval M, Carmichael PH, Giroux I, Jacques C, Demers MF, Roy MA. Problem Gambling Associated with Aripiprazole: A Nested Case-Control Study in a First-Episode Psychosis Program. CNS Drugs. 2021 Apr;35(4):461-468. doi: 10.1007/s40263-021-00801-4. Epub 2021 Mar 13.

  PMID: 33713298 BACKGROUND

• Corbeil O, Corbeil S, Giroux I, Jacques C, Dorval M, Demers MF, Roy MA. Problem Gambling Associated With Aripiprazole in First-Episode Psychosis Patients: A Series of 6 Case Reports. J Clin Psychopharmacol. 2020 Mar/Apr;40(2):191-194. doi: 10.1097/JCP.0000000000001177.

  PMID: 32134855 BACKGROUND

• Lachance A, Corbeil O, Corbeil S, Chalifour G, Breault AS, Roy MA, Demers MF. Case Reports of Aripiprazole and Problematic Gambling in Schizophrenia: A Critical Review of the Evidence. J Clin Psychopharmacol. 2019 Jul/Aug;39(4):393-397. doi: 10.1097/JCP.0000000000001068.

  PMID: 31206391 BACKGROUND

• Desai RA, Potenza MN. A cross-sectional study of problem and pathological gambling in patients with schizophrenia/schizoaffective disorder. J Clin Psychiatry. 2009 Sep;70(9):1250-7. doi: 10.4088/JCP.08m04359. Epub 2009 Jun 16.

  PMID: 19538900 BACKGROUND

• Haydock M, Cowlishaw S, Harvey C, Castle D. Prevalence and correlates of problem gambling in people with psychotic disorders. Compr Psychiatry. 2015 Apr;58:122-9. doi: 10.1016/j.comppsych.2015.01.003. Epub 2015 Jan 15.

  PMID: 25684263 BACKGROUND

• Bergamini A, Turrina C, Bettini F, Toccagni A, Valsecchi P, Sacchetti E, Vita A. At-risk gambling in patients with severe mental illness: Prevalence and associated features. J Behav Addict. 2018 Jun 1;7(2):348-354. doi: 10.1556/2006.7.2018.47. Epub 2018 Jun 5.

  PMID: 29865864 BACKGROUND

• Corbeil O, Soulard M, Huot-Lavoie M, Bechard L, Fournier E, Brodeur S, Essiambre AM, Desmeules C, Theriault C, Abdel-Baki A, Jacques C, Giroux I, Dorval M, Roy MA, Demers MF. Problem gambling among people with first-episode psychosis: protocol for a prospective multicenter cohort study. BMC Psychiatry. 2023 Apr 25;23(1):287. doi: 10.1186/s12888-023-04741-9.

  PMID: 37098506 DERIVED

MeSH Terms

Conditions

Gambling; Psychotic Disorders; Schizophrenia

Interventions

Social Class

Condition Hierarchy (Ancestors)

Risk-Taking; Behavior; Disruptive, Impulse Control, and Conduct Disorders; Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders

Intervention Hierarchy (Ancestors)

Socioeconomic Factors; Population Characteristics

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PharmD, MSc, Pharmacist, Principal Investigator

Study Record Dates

• First Submitted: December 29, 2022
• First Posted: January 17, 2023
• Study Start: November 1, 2019
• Primary Completion: May 1, 2023
• Study Completion: May 1, 2023
• Last Updated: May 28, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)