Relation Between Substance Use and Pain, in Patients Suffering or Surviving From Cancer and Followed in France

NCT05684939 | Completed

• 1 other identifier: RNI 2022 BALAYSSAC
• Study Type: observational
• Target: 2,010
• Locations: 1 country
• Sites: 1

Brief Summary

Pain is one of the most prevalent symptoms during and after cancer. Pain can be the consequence of several situations (disease progression, surgery, and anticancer drugs). However, pain can frequently be associated with a substance use disorder (alcohol, tobacco, drugs, and illicit products such as cannabis). The relationship between substance use and pain is known to be complex and interdependent, i.e. pain can reinforce substance use and substance use can promote pain. However, few data in the literature are available on the use of psychoactive substances in relation to pain in the context of cancer (cancer patients and cancer survivors). Moreover, the scientific literature agrees on the fact that these elements are little studied and underestimated in the clinic. The investigators hypothesize that, in cancer patients or cancer survivors, the prevalence of the use of psychoactive substances would be higher in the presence of pain, and would be associated with its intensity and its impact on the quality Health-Related Living (HRQoL). The main objective of this study will be to compare, in an adult population of patients suffering from cancer or having had cancer, the prevalence of the consumption of psychoactive substances in painful patients compared to non-painful patients.

Conditions

Cancer; Pain; Substance Use

Outcome Measures

Primary Outcomes (1)

• substance use

  Legal: alcohol, tobacco, electronic cigarette, psychotropic drugs (benzodiazepines, z-drugs, and opioids), CBD, and other susbtances Illegal: cannabis, and other drugs At least once in the past year, at least once in the past month, at least once in the past week, or at least once a day

  day 1

Secondary Outcomes (10)

• Pain severity

  day 1

• Neuropathic pain

  day 1

• Analgesic use

  day 1

• Chemotherapy-induced peripheral neuropathy

  day 1

• Health-related quality of life and symptoms

  day 1

Study Arms (1)

cancer patients and cancer survivors

answer to an online questionnaire

Behavioral: Questionnaire (patient reported outcome)

Interventions

Questionnaire (patient reported outcome) BEHAVIORAL

Online self-administered questionnaire exploring substance use, pain, chemotherapy-induced peripheral neuropathy, health-related quality of life, anxiety, depression, social and material deprivation, patients and oncological charactericitcs, and intercurrent pathologies

cancer patients and cancer survivors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cancer patients and cancer survivors recruited thanks to associations of cancer patients and social networks

You may qualify if:

• \- Adult patient, male or female, declaring himself as suffering or having suffered from cancer and recruited as such via appropriate communication systems (patient associations, etc.)

You may not qualify if:

• Difficulty to understand French language
• Residence outside France (will be verified by the information from the department at the start of the questionnaire)
• Patient close relative
• Protected adults

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU Clermont-Ferrand

Clermont-Ferrand, France

Location

MeSH Terms

Conditions

Neoplasms; Pain; Substance-Related Disorders

Interventions

Surveys and Questionnaires; Patient Reported Outcome Measures

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Chemically-Induced Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Health Care Surveys; Health Services Research; Health Planning; Health Care Economics and Organizations; Patient Outcome Assessment; Outcome Assessment, Health Care; Outcome and Process Assessment, Health Care; Health Services Administration

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 4, 2023
• First Posted: January 13, 2023
• Study Start: January 27, 2023
• Primary Completion: March 20, 2023
• Study Completion: March 20, 2023
• Last Updated: June 13, 2023

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)